Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Transformation of science and technology systems into systems of innovation in Central and Eastern Europe: the emerging patterns and determinants [PDF]
, 1999 This paper explores patterns of transformation of socialist Science and Technology (S&T) systems into post-socialist systems of innovation and their determinants.
Radosevic, S
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
New Social Policy Ideas in the Making: The Case of Central and Eastern Europe [PDF]
Central and Eastern European countries have experienced a rapid transformation of their economic, political and welfare regime(s). From a state-paternalist welfare state, post-communist countries are now moving towards something new.
Cerami, Alfio
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Jewish Women, Identity, and the Aufklärung: The German-speaking Enlightenment around 1800
Central EuropeThis paper poses the question, “how enlightened was German-speaking central Europe around 1800?” The initial idea was to explore how marginalized groups accessed the German Enlightenment.
Josephine Porter
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Lerntag of the American Federation of Jews from Central Europe papers [PDF]
, 1965 American Federation of Jews from Central Europe
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Corporate Environmental Management in Transition Economies: The Case of Central and Eastern Europe [PDF]
The authors study the adoption of environmental management practices in the most polluting industrial sectors in Bulgaria, Hungary, Lithuania, Poland, Romania and Slovakia during the first years of transition from central planning to market economies ...
Jorge H. García +2 more
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