Results 71 to 80 of about 470,056 (261)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Whether Social Participation Can Affect the Central Government Public Policy Response to the COVID-19 in China. [PDF]

Front Public Health, 2022
Fu L, Sun H, Xu K.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

On New Sequences of $p$-Binomial and Catalan Transforms of the $k$-Mersenne Numbers and Associated Generating Functions

Universal Journal of Mathematics and Applications
In this work, we investigate the binomial transforms and Catalan transform of the $k$-Mersenne and $k$-Mersenne-Lucas numbers and examine the new integer sequences.
Kalika Prasad, Hrishikesh Mahato, Ritanjali Mohanty, Munesh Kumari   +3 more
doaj   +1 more source

Exploring time evolution characteristics of the collaborative mode in emergency information release of public health emergencies: A network analysis of response to COVID-19 from the central government of China. [PDF]

Front Public Health, 2022
Liu J, Song Y, An S, Dong C, Lian C.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Lead by Relationship: The Behaviors of Relational Leadership in Regional Collaborative Governance

Systems
Leadership lies at the core of public administration, yet research on boundary-spanning leadership has paid limited attention to the micro-level behaviors through which regional collaboration is enacted.
Hua Xing, Lin Luo, Bo Feng
doaj   +1 more source

Groundwater quality variations in Precambrian hard rock aquifers: a case study from Kerala, India

Applied Water Science, 2019
Analytical data of groundwater samples collected from weathered and deep fractured zones in the Precambrian charnockite aquifers in Kerala, India, have been studied to understand their hydrochemical variations and reasons thereof.
P. Nandakumaran, K. Balakrishnan
doaj   +1 more source