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Functional central hypothyroidism in the elderly
Aging Clinical and Experimental Research, 2008Previous studies have shown that blood concentrations of free thyroxin and basal thyroid-stimulating hormone (TSH) decrease during adult life. Suggested mechanisms include reduced thyroid activity resulting from decreased serum TSH concentrations, impairment of peripheral 5'-deiodinase, and an increase in reverse 3,5,3'-triiodothyronine due to non ...
Maren A, Sell +5 more
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Genetic aspects of central hypothyroidism
Journal of Endocrinological Investigation, 2000Central hypothyroidism, characterized by insufficient TSH secretion in the presence of low levels of thyroid hormones, is a rare disorder. It has recently been found that, although mainly due to tumors or infiltrative diseases of the hypothalamo-pituitary area or to pituitary atrophy, central hypothyroidism may be caused by inactivating mutations in ...
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Cranial irradiation and central hypothyroidism
Trends in Endocrinology & Metabolism, 2001Cranial irradiation causes thyrotropin (TSH)-releasing hormone (TRH) secretory abnormalities. TRH deficiency leads to abnormal glycosylation of TSH alpha and beta subunits and loss of the normal circadian pattern of TSH secretion (low in the afternoon, a surge in the evening, higher at night).
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Genetically Determined Central Hypothyroidism
Journal of Genetic Syndromes & Gene Therapy, 2013Central, secondary or low TSH hypothyroidism can be congenital or acquired. Congenital Central hypothyroidism (CH-C), either isolated or (unlike primary hypothyroidism) combined with deficiency of other pituitary hormones, is usually caused by mutations in genes related either to TSH synthesis or pituitary ontogenesis.
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Brain and other central nervous system tumor statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021Kimberly D Miller +2 more
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Central hypothyroidism: consequences in adult life.
Journal of pediatric endocrinology & metabolism : JPEM, 2001Central hypothyroidism (CH) is a rare cause of hypothyroidism, generally due to either pituitary or hypothalamic defects. On the basis of its etiology, it is possible to distinguish acquired and hereditary forms. Hereditary CH can be isolated or associated with combined pituitary hormone deficiency (CPHD).
C. Asteria, L. Persani, P. Beck-Peccoz
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Decreased Receptor Binding of Biologically Inactive Thyrotropin in Central Hypothyroidism
New England Journal of Medicine, 1985Sania Amr
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