Results 231 to 240 of about 1,405,360 (315)

Assessing human-scale green equity in the 15-minute city using street-view-based visual landscape indicators and explainable machine learning: a case study of Chengdu, China. [PDF]

Front Public Health
Yan S, Ma Y, Wang X.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Inconsistent associations between central and peripheral arterial stiffness indices in relation to age. [PDF]

Quant Imaging Med Surg
Xi G, Chen A, Dong J, Ma J, Wang N, Yang L, Wang X, Li X, Jiang X, Jin L, Li Z.   +10 more
europepmc   +1 more source

[cs]REC: Interventional Cardiology[/cs] is now indexed in PubMed Central, the ultimate indexing

REC: interventional cardiology (English Edition)
de la Torre-Hernández, José M., Alfonso, Fernando, Moreno, Raúl, Ojeda, Soledad, de Prado, Armando Pérez, Romaguera, Rafael   +5 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Association of the Triglyceride-Glucose Index and Its Central Obesity Derivatives with Peripheral Artery Disease in Type 2 Diabetes: A Cross-Sectional Study. [PDF]

Diabetes Metab Syndr Obes
Guo Y, Zhou X, Chen L, Zheng J.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Associations of inflammatory biomarkers with brain atrophy and clinical scores in schizophrenia patients with autistic features. [PDF]

BMC Res Notes
Wang J, Shen J, Pang Y, Liu J, Zhao L, Sun M, Yang Y.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stochastic analysis of compact stars under composite polytropes. [PDF]

Sci Rep
Nouh MI, El-Essawy SH, Foda MM, Aboueisha MS.   +3 more
europepmc   +1 more source