Results 91 to 100 of about 17,389,371 (292)

Zero risk for central line-associated bloodstream infections … is this realistic?* [PDF]

Critical Care Medicine, 2012
Central line associated bloodstream infections (CLABSI) are one of the most common healthcare associated infections and result in morbidity, prolonged hospitalizations, and increased healthcare costs [1–3]. Over the past decade, and particularly since the Institute of Medicine put hospital-acquired infections in the category of “preventable adverse ...
openaire   +2 more sources

High Prevalence of Tuberculosis and Serious Bloodstream Infections in Ambulatory Individuals Presenting for Antiretroviral Therapy in Malawi [PDF]

, 2011
Background Tuberculosis (TB) and serious bloodstream infections (BSI) may contribute to the high early mortality observed among patients qualifying for antiretroviral therapy (ART) with unexplained weight loss, chronic fever or chronic diarrhea. Methods
Ramsay Andrew R., Åkesson, A, Ann Akesson, Polis, M A, Corbett, E L, Ramsay, Andrew R, Anderson Suzanne T. B., Heyderman, R S, Harries, Anthony D, Zachariah Rony, Chan, A K, Adrienne K Chan, Elizabeth L Corbett, Heyderman Robert S., van Lettow, M, Robert S Heyderman, Chan, Adrienne K, Anderson, S T B, Richard A Bedell, Ramsay, A R, Chan Adrienne K., Zachariah, Rony, Harries, A D, Kumwenda, Moses, Kumwenda, M, Akesson, Ann, Corbett, Elizabeth L, Anderson, Suzanne TB, Anderson, Suzanne T B, Suzanne T B Anderson, Anthony D Harries, Zachariah, R, Bedell, R A, Corbett Elizabeth L., Monique van Lettow, Åkesson Ann, Andrew R Ramsay, Bedell, Richard A, van Lettow Monique, Kumwenda Moses, Bedell Richard A., Harries Anthony D., van Lettow, Monique, Heyderman, Robert S, Moses Kumwenda, Rony Zachariah   +45 more
core   +2 more sources

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

Sustained Low Incidence Rates of Central Line-Associated Blood Stream Infections in the Intensive Care Unit

Infection and Drug Resistance, 2021
Waleed A Mazi,1 Mohammed H Abdulwahab,1 Mahmood A Alashqar,1 Yvonne S Aldecoa,1 Zaheda R Bahat,1 Jennifer L Suaking,1 Amir Saeed,2,3 Osama S Yassin,4 Salah Al-Din Mahfouz,5 Abiola Senok6 1Infection Prevention and Control, King Faisal Medical Complex ...
Mazi WA, Abdulwahab MH, Alashqar MA, Aldecoa YS, Bahat ZR, Suaking JL, Saeed A, Yassin OS, Mahfouz SA, Senok A   +9 more
doaj  

Construção de um guia de cuidados de enfermagem para a prevenção de incidentes na via intravenosa: implicações para a segurança do paciente pediátrico [PDF]

, 2015
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Gestão do Cuidado em Enfermagem, Florianópolis, 2015.A segurança do paciente nos serviços de saúde é um tema que vem ...
Soncini, Marília de Farias
core  

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Best Practice: Implementation of a Central Line Bundle to Reduce Central Line-Associated Bloodstream Infections [PDF]

Central line-associated bloodstream infections (CLABSIs) are among the most frequent health care-associated infections and are reported to be correlated with an increased number of inpatient days, higher cost, and attributable mortality rates (Devrim et ...
Montero, Alexis N
core   +2 more sources

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci, Carlotta Bidoli, Marco Gerdol, Charisse Winston, Robert A. Rissman, Giuliana Decorti, Antonella Fabretto, Andrea Taddio, Gabriele Stocco, Erik Roman‐Pognuz, Marianna Lucafò   +10 more
wiley   +1 more source

Systematic review of clinical trials and cohort studies evaluating HIV post‐exposure prophylaxis (PEP) regimens to inform updated Canadian guidelines

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background We conducted a systematic review of clinical trials and cohort studies on HIV post‐exposure prophylaxis (PEP) regimens to inform updated 2025 Canadian guidelines. Methods We searched Medline and Embase (July 2017–June 2024) for studies reporting on: HIV acquisition, PEP completion, adverse events (AEs) leading to discontinuation and/
Stanley O. Onyegbule, Maryam Habib, Rija Khalid, Jessie Tu, Deborah Yoong, Jaris Swidrovich, Wale Ajiboye, Patrick O'Byrne, Ameeta E. Singh, Jean‐Guy Baril, Tatiana Sotindjo, Mark W. Hull, Darrell H. S. Tan   +12 more
wiley   +1 more source