Results 221 to 230 of about 17,389,371 (292)

Systemic RVX‐208 Attenuates Experimental Periodontitis Through Inflammatory Host Modulation

Journal of Periodontal Research, EarlyView.
Prophylactic systemic treatment with RVX‐208 mitigated alveolar bone loss in experimental periodontitis. In THP‐1 cells, transcriptomic analysis showed that RVX‐208 downregulated inflammatory gene expression associated with Pg, and it produced a more moderate and limited effect on global gene expression than the pan‐BET inhibitor JQ1.
Sheikh Alam, Simrah Ansari, Birtan T. Yilmaz, David J. Cohen, James Sugai, Caroline Carrico, Melissa Morgan, Matthew S. Halquist, Sinem Esra Sahingur, Barbara D. Boyan, Zvi Schwartz, William V. Giannobile, Zhao Lin   +12 more
wiley   +1 more source

A Population Pharmacokinetic Model of Gentamicin in Hospitalized Neonatal Foals

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Information on safe and effective gentamicin dosing in foals is limited. This study aimed to provide guidance regarding optimal dosing regimens by means of a population pharmacokinetic (popPK) model. Gentamicin plasma concentration of 290 samples from 72 hospitalized foals (≤ 14 days old), treated with intravenous (IV) gentamicin, was measured
Astrid J. van den Brom‐Spierenburg, Esther A. Winter, Mathijs J. P. Theelen, Ingeborg M. van Geijlswijk, Cornélie M. Westermann, Marianne M. Sloet van Oldruitenborgh‐Oosterbaan, Tim Florschütz, Johannes C. Vendrig, Esther W. Siegers, Kim de Graaf, Marc Cherlet, Mathias Devreese, Ronette Gehring   +12 more
wiley   +1 more source

Treatment outcomes in pediatric intestinal failure patients with ambulatory Candida central line-associated bloodstream infections with and without central venous line removal: A retrospective case series. [PDF]

Nutr Clin Pract
Khan HH, Jump CS, Bauer J, Wu Q, Thacker S, Eckard AR.   +5 more
europepmc   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

A Retrospective Study of Central Line-Associated Bloodstream Infections in Children Treated With Hemodialysis in a Tertiary Care Center. [PDF]

Cureus
Al Qahtani AT, AlSumih N, Al Rasheed SA, Alamir A.   +3 more
europepmc   +1 more source