Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Cryptococcus laurentii Bloodstream Infection in an Immunocompetent Adult: A Rare Central Line-Associated Infection Complicating Extended-Spectrum Beta-Lactamase Klebsiella pneumoniae Bacteremia. [PDF]
CureusAbu Baker K +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Catheter-Associated Urinary Tract Infections (CAUTI) and Central Line-Associated Bloodstream Infections (CLABSI) in Critical Care Units of a Tertiary Care Hospital: A Retrospective Surveillance Study. [PDF]
CureusPrasad A +7 more
europepmc +1 more source
Knowledge, attitude, and practice of central line-associated bloodstream infection prevention among intensive care unit nurses in Hebei Province, China: a cross-sectional study. [PDF]
Front Public HealthLi J, Li Z, Wang L, Liu X, Zhu J.
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Incidence and risk factors for hospital-attributable central line-associated bloodstream infections in adult inpatients in a tertiary hospital. [PDF]
Antimicrob Steward Healthc EpidemiolArora S +11 more
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Catheter Duration Threshold and Risk Factors for Central Line-Associated Bloodstream Infections in a Tertiary ICU with Endemic Carbapenem Resistance: A Case-Control Study. [PDF]
Antibiotics (Basel)Dalmanoğlu E +3 more
europepmc +1 more source