Results 11 to 20 of about 270 (106)

Methodological insights and clinical outcomes in ALS and FTLD: lessons from the SPIN cohort. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) constitute a clinico‐genetic‐neuropathological continuum with marked heterogeneity. Reliable in vivo biomarkers of the disease are lacking. Large, multimodal cohorts are needed to advance biomarker discovery and precision medicine. METHODS We describe
Carbayo Á, Turon-Sans J, Alcolea D, Cortés-Vicente E, Cabezas-Torres M, Alvarez-Sanchez E, Muñoz L, Rubio-Guerra S, García-Castro J, Selma-González J, Bernal S, Gonzalez-Quereda L, Bejanin A, Aranha MR, Santos-Santos M, Belbin O, Vesperinas-Castro A, Collet-Vidiella R, Caballero-Ávila M, Llansó L, Querol L, Lleó A, Fortea J, Gelpí E, Dols-Icardo O, Illán-Gala I, Rojas-Garcia R.   +26 more
europepmc   +2 more sources

A randomized phase II trial of gemcitabine, nab-paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer. [PDF]

Cancer
ABSTRACT Background A randomized phase II screening trial of gemcitabine, nab‐paclitaxel, and cisplatin with a medically supervised ketogenic diet (MSKD) versus usual diet (non‐MSKD) was conducted in patients with treatment‐naive metastatic pancreatic ductal adenocarcinoma (PDAC).
Jameson GS, Roe DJ, Borazanci E, Hanna DL, Roberts CGP, Pelster MS, Frank RC, Alistar AT, Miller AM, Wiedmeier-Nutor JE, Algaze SD, Zoller AR, Hallberg SJ, Wertheim BC, Lee K, Cridebring D, Rabinowitz JD, Gately S, Keppler J, Sharma S, Von Hoff DD, Rasco DW.   +21 more
europepmc   +2 more sources

Effect of Eplontersen in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy Across Genetic Variants: An Exploratory Analysis From the NEURO-TTRansform Trial. [PDF]

Eur J Neurol
In this exploratory analysis of the NEURO‐TTRansform Phase 3 trial, the efficacy of eplontersen was evaluated in patients with early‐ or late‐onset Val30Met (p.Val50Met) or non‐Val30Met hereditary transthyretin amyloidosis with polyneuropathy. Eplontersen halted neuropathy impairment as measured by the mNIS+7 composite score and improved Norfolk QoL‐DN
Gillmore JD, Adams D, Weiler M, Masri A, Obici L, Nåtman J, Kwoh TJ, Reicher B, Revkin J, Cruz MW, Gertz M, Chao CC.   +11 more
europepmc   +2 more sources

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

The use of real‐world data in health services research for dementia care: A scoping review

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 4, December 2026.
Abstract Health services research (HSR) is critical to informing dementia care and often relies on real‐world data (RWD); however, RWD use in HSR has not been systematically mapped in the United States. Following previous researchers and Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR ...
Ashley Kuzmik, Arpita Tripathi, Laura M. Block, Oluwagbemiga Oyinlola, Pedro JDMR Pinho, Zahra Rahemi, Pallavi Tyagi, Lycia Tramujas Vasconcellos Neumann   +7 more
wiley   +1 more source

Molecular investigation of the phylogenetic placement of Kartalinia and a revision of Bituminaria (Fabaceae: Psoraleeae)

TAXON, Volume 75, Issue 4, August 2026.
Abstract The genus Kartalinia was described to accommodate a single, obscure species, Psoralea acaulis, based on its unique morphology and karyology. No concerted molecular phylogenetic studies were available for this species at the time, and therefore its phylogenetic position was uncertain.
Brian Du Preez, Salvatore Brullo, Charles H. Stirton, Salvatore Cambria, A. Muthama Muasya   +4 more
wiley   +1 more source

The SWITCH algorithm: An expert consensus on treat‐to‐target criteria for chronic prurigo

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 7, Page 1185-1194, July 2026.
The SWITCH project assessed patients' most distressing symptoms and therapy goals, followed by an expert‐based consensus procedure to define T2T criteria for patients with chronic prurigo (CPG)/prurigo nodularis. Based on these validated criteria, a 4‐step SWITCH algorithm was established to enhance CPG therapy outcomes and reduce patient burden ...
Lea S. Stahl, Claudia Zeidler, Joyce Loewenthal, Svenja Royeck, Matthias Augustin, Robert Bissonnette, Sarina Elmariah, Brian S. Kim, Laurent Misery, Hiroyuki Murota, Hong Liang Tey, Elke Weisshaar, Gil Yosipovitch, Franz J. Legat, Adam Reich, Martin Metz, Sonja Ständer   +16 more
wiley   +1 more source

The cost of dementia in the United States in 2026

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Comprehensive cost measurement is essential for an effective policy response to societal dementia costs. METHODS Using dynamic microsimulation, the Health and Retirement Study, and other national data, we quantified the 2026 cost of dementia in the United States. RESULTS In 2026, 5.7 million (95% confidence interval [CI] [5.6, 6.0]
Johanna Thunell, Bryan Tysinger, Matthew Baumgart, Maria Carrillo, Eileen Crimmins, Dana Goldman, Hanke Heun‐Johnson, Mireille Jacobson, Geoff Joyce, Duncan Leaf, Lycia Tramujas Vasconcellos Neumann, Julie Zissimopoulos   +11 more
wiley   +1 more source

Bridging research, policy, and practice: Advancing evidence‐informed approaches for dementia care and prevention: An expert review by the Health Policy Professional Interest Area from ISTAART

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract Bridging dementia research and policy remains a global challenge, with gaps in governance, capacity, data infrastructure, and contextual fit limiting the development and implementation of effective national dementia plans. To inform this issue, the Health Policy Professional Interest Area of the International Society to Advance Alzheimer's ...
Juliana Souza‐Talarico, Maria M. Pinzon, Jayalakshmi Viswanathan, Tuan Anh Nguye, Walter D. Dawson, Jay Lusk, Crystal Glover, Perlina Desai, Anna Shelander, Lesley E. Williamson, Dallas Seitz, Joseph M. Costello, Magdalena Pereyra, Yixuan Cheng, Sharon Naismith, Andrea Slachevsky, Lycia Tramujas Vasconcellos Neumann, Preeti Pushpalata Zanwar   +17 more
wiley   +1 more source

Mitigating disparities in diagnosis of dementia

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract The field of Alzheimer's disease and related dementias (AD/ADRD) is undergoing a transformative shift with a better understanding of disease biology, biomarker‐based diagnostics, and disease‐modifying therapies. Yet, these advancements risk exacerbating existing disparities in diagnosis and care.
Lycia Tramujas Vasconcellos Neumann, Simin Mahinrad, Erin Abner, Soo Borson, Goldie S. Byrd, Maria C. Carrillo, Lindsay Clark, Anthony N. Correro II, Kacie D. Deters, Peggye Dilworth‐Anderson, Rebecca M. Edelmayer, Jason D. Flatt, Crystal M. Glover, Joshua D. Grill, Carl V. Hill, Thomas K. Karikari, Fred B. Ketchum, Emily A. Largent, Jennifer H. Lingler, Jose A. Luchsinger, Gladys E. Maestre, Michelle M. Mielke, Sid O'Bryant, Ozioma C. Okonkwo, Monica W. Parker, Annalise M. Rahman‐Filipiak, Rema Raman, Suzanne E. Schindler, Jose Soria Lopez, Shana D. Stites, Astrid M. Suchy‐Dicey, Whitney Wharton, Rachel A. Whitmer, Lisa Ann Kirk Wiese, Charles C. Windon, Amy Kind, Lisa L. Barnes   +36 more
wiley   +1 more source