Results 41 to 50 of about 24,227,038 (179)

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Decoding neurodevelopment risks of exposures to intoxication, infection, and trauma during pregnancy

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract The maternal environment plays a pivotal role in fetal neurodevelopment, but adverse conditions during pregnancy may disrupt key developmental processes. Conditions such as intoxication, infection, or trauma during pregnancy have been associated with impaired fetal oxygenation, altered immune signaling, and disrupted placental function, which ...
Brenda E. Lujan, Katherine R. Giordano, Rafael Jaime Gonzalez‐Ricon, Olivia C. Giblin, Maria Manriquez, Shenfeng Qiu, Adrienne M. Antonson, Jonathan Lifshitz   +7 more
wiley   +1 more source

Antimicrobial Therapy for Central Nervous System Infections

, 2018
Broad-spectrum antibiotics—those that are bactericidal and able to penetrate the blood–brain barrier—must be administered to any patient with a suspected infection of the central nervous system (CNS).
Sarah L. Clark, Eelco F. M. Wijdicks
core   +1 more source

Clinical Molecular Investigation of Encephalitozoon cuniculi in Pet Rabbits: Early Detection of Potential Risk for Animal and Human Infection

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study assesses the presence, genotypes and clinical signs of E. cuniculi infection in pet rabbits in Slovenia. Molecular analysis reveals the presence of E. cuniculi DNA (Genotype I) in 14.98% rabbit urine samples, mostly in rabbits with signs of urinary tract disorders.
Maruša Škrbec, Brigita Slavec, Nina Kočar, Katarina Modrijan, Urška Kuhar, Marko Kolenc, Alenka Dovč, Olga Zorman Rojs, Jožko Račnik   +8 more
wiley   +1 more source

A Review on Heat Stress in Broiler Chickens: Mechanisms, Effects and Mitigation Strategies

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Heat stress caused by high temperature and humidity compromises broiler health, welfare, and productivity by reducing feed intake, growth performance, and feed efficiency, while increasing mortality, oxidative stress, metabolic disturbances, intestinal dysfunction, gut dysbiosis, immune suppression, and meat quality deterioration.
Maksuda Begum, Laura Musa, Guido Grilli, Dilşan Akçay, Md Golam Kibria, Mst. Mayeeda Parvin, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed, Delower Hossain   +8 more
wiley   +1 more source

Continuous electroencephalographic monitoring in critically ill patients with central nervous system infections

, 2008
To determine the prevalence, predictors, and clinical significance of electrographic seizures (ESz) and other continuous electroencephalographic monitoring findings in critically ill patients with central nervous system ...
Emerson, Ronald G, Mayer, Stephan A, Claassen, Jan, Oddo, Mauro, Hirsch, Lawrence J, Carrera, Emmanuel, Claassen, J., Carrera, E., Oddo, M., Emerson, R.G., Hirsch, L.J., Mayer, S.A.   +11 more
core   +1 more source

Brain endothelial spheroids and cortical organoids reveal the impact of Toxoplasma gondii lineage and host-phagocyte-pathogen interactions on colonization

Cellular and Molecular Life Sciences
Toxoplasma gondii chronically infects the central nervous system (CNS), but the mechanisms enabling its traversal of the blood-brain barrier (BBB) remain unclear. Here, we investigated BBB penetration using brain endothelial spheroids and cerebral tissue-
Matias E. Rodriguez, Elena Afanaseva, Ali Hassan, Felix Harryson-Oliveberg, Antonio Barragan   +4 more
doaj   +1 more source

COMPARATIVE STUDIES IN THE CHEMISTRY OF BLOOD AND CEREBROSPINAL FLUID

, 1921
Chemistry plays an ever-increasing role in the practice of medicine; in the field of metabolism it is the alpha and omega. Medical chemistry deals largely with studies of body fluids and gases. The urine, because of its accessibility, was the first to be
Grete Egerer-Seham, C. E. Nixon
semanticscholar   +1 more source

Laboratory investigation of fungal infections of the central nervous system [PDF]

, 2007
While fungal infections of the central nervous system (CNS) are relatively rare, fungal pathogens are increasingly being recognized as an important etiology of CNS infections, particularly amongst the growing immunocompromized population.
Davis, John A., Venna, Nagagopal, Costello, Daniel J.   +2 more
core   +1 more source

Feline Immunodeficiency

, 2012
FIV causes immune dysfunctions in cats similar to those observed in people infected with human immunodeficiency virus (HIV). Diseases associated with FeLV and FIV may affect some organ, and may cause among other disorders, lymphoma, blood dyscrasias ...
F. Alves, J. K. Pimenta dos Reis
semanticscholar   +1 more source