Results 111 to 120 of about 1,548,347 (335)
Demonstration and Optimization of Thermoelectric Converter on Central Processing Unit of Server
, 2023 Xuehong Zhang +6 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
TINJAUAN YURIDIS PENGELOLAAN LIMBAH RUMAH TANGGA DALAM UPAYA PENGENDALIAN PENCEMARAN LIMBAH DOMESTIK OLEH UNIT INSTALASI PENGOLAHAN AIR LIMBAH (IPAL) MOJOSONGO PERUSAHAAN DAERAH AIR MINUM (PDAM) DI KOTA SURAKARTA [PDF]
, 2013 This research aimed to find out the process of domestic waste management by the Mojosongo Liquid Waste Processing Installation (IPAL) unit of Local Drinking Water Enterprise (PDAM) in Surakarta City, and to find out the management of domestic waste based
Arkedina, Vina
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Automatic oscillator frequency control system [PDF]
, 1985 A frequency control system makes an initial correction of the frequency of its own timing circuit after comparison against a frequency of known accuracy and then sequentially checks and corrects the frequencies of several voltage controlled local ...
Smith, S. F.
core +1 more source
Engineering ProceedingsMultipliers are crucial components in digital processing and the arithmetic logic unit (ALU) of central processing unit (CPU) design. As the data bit length increases, the number of partial products in the multiplication process increases, resulting in ...
Yu-Nsin Wang, Yu-Cherng Hung
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source