Results 131 to 140 of about 56,105 (222)

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Advanced Science, EarlyView.
Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier   +24 more
wiley   +1 more source

Ethical and legal considerations in healthcare AI: innovation and policy for safe and fair use. [PDF]

R Soc Open Sci
Pham T.
europepmc   +1 more source

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

A common outcome set for trials in dementia with Lewy bodies (DLB COS). [PDF]

Alzheimers Dement (N Y)
Kane JPM, Fitzpatrick RL, Betzhold S, Daly G, Kalfas E, Kinchin I, Aarsland D, Greaney K, Grycuk E, Folkerts AK, Kalbe E, Rodriguez-Porcel F, Saldanha IJ, Smith V, Taylor JP, Thompson R, Wyman-Chick K, Leroi I, and The DLB COS Delphi Group.   +18 more
europepmc   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Brazil was certified by the World Health Organization for having eliminated lymphatic filariasis: what now? [PDF]

Parasit Vectors
Brandão E, Oliveira P, da Silva MAL, Rocha A.   +3 more
europepmc   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Alistipes senegalensis is Critically Involved in Gut Barrier Repair Mediated by Panax Ginseng Neutral Polysaccharides in Aged Mice

Advanced Science, EarlyView.
An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang, Hui Wang, Yingna Li, Jing Lu, Xiaolei Tang, Dan Yang, Manying Wang, Daqing Zhao, Fangbing Liu, Shuai Zhang, Liwei Sun   +10 more
wiley   +1 more source

Framing alcohol harm in the UN context - the importance of language. [PDF]

Global Health
Bakke Ø, Casswell S.
europepmc   +1 more source

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, EarlyView.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source