Results 251 to 260 of about 742,194 (304)

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

The PICO Puzzle: Can Public Data Predict EU HTA Expectations for All EU Countries? [PDF]

J Mark Access Health Policy
Eberle K, Hagemann LM, Schweitzer MK, Justl M, Maurer J, Carls A, Reuter EM.   +6 more
europepmc   +1 more source

Single‐Cell Transcriptomics Unravels Growth Factor Erv1‐Like Mediated Ferroptosis as a Key Driver of Intestinal Epithelial Dysfunction in Ulcerative Colitis

Advanced Science, EarlyView.
Single‐cell transcriptomic profiling of ulcerative colitis (UC) tissues identified downregulation of GFER in intestinal epithelial cells. Mechanistically, GFER interacts with PCBP1 to help maintain intracellular iron homeostasis and may also reduce lipid peroxidation by activating the PGC‐1α/PPARγ signaling pathway, thereby inhibiting ferroptosis ...
Ya Song, Fangyan Tan, Qian Song, Xiaohui Liao, Zhechuan Mei, Lin Lv   +5 more
wiley   +1 more source

The paradoxical impact of drought on West Nile virus risk: insights from long-term ecological data. [PDF]

Proc Biol Sci
Sambado S, Sipin TJ, Rennie Z, Larsen A, Cunningham J, Quandt A, Sousa D, MacDonald AJ.   +7 more
europepmc   +1 more source

Preparation of Czech public administration for EU membership [PDF]

, 2002
-, -
core  

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

A socioenvironmental approach to the nosogenic potential of freshwaters with presence of thermotolerant free-living amoebae in Costa Rica. [PDF]

Front Public Health
Alvarado-Ocampo J, Romero Zúñiga JJ, Castro J, Chaves Monge F, Ruiz Campos M, Bustamante Cortés A, Abrahams Sandí E, Retana Moreira L.   +7 more
europepmc   +1 more source

Personnel reshuffle in regions echo battles in Kyiv [PDF]

, 2002
Tyshchenko, Yulia
core  

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

Advanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao, Yixing Huang, Mingcong Deng, Chunkai Zhang, Dan Zu, Hanyi He, Yangchan Hu, Yuke Zhong, Chen Liang, Haidong Liu, Wumin Dai, Yanhua He, Yaoshu Teng, Ji Jing, Yin Shi, Xiangdong Cheng, Zu Ye   +16 more
wiley   +1 more source

Schistosomiasis Interventions in Africa: Assessment and Systematic Review. [PDF]

J Parasitol Res
Dumevi CY, Kyei GB, Tetteh-Quarcoo PB, Kretchy JP, Ayi I, Ayeh-Kumi PF.   +5 more
europepmc   +1 more source