Results 191 to 200 of about 232,248 (229)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Reading skills modulate the audiovisual congruency effect in orthographic processing in children: an ERP study. [PDF]

Front Hum Neurosci
Lutz CG, Coraj S, Kressebuch A, Di Pietro SV, Karipidis II, Brem S.   +5 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Response to the letter to the editor. [PDF]

J Orthop Surg Res
Zhao T, Zhang K, Li J, Fu W.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Insights into perceptual learning. [PDF]

Elife
Lu ZL.
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Improved Efficiency and Lesion Detection in Small Bowel Capsule Endoscopy Using the Open-Source Artificial Intelligence Model SEE-AI. [PDF]

DEN Open
Miyazono S, Umeno J, Nagasue T, Saiki T, Kaku H, Torisu T, Yokote A, Kawasaki K, Ihara Y, Matsuno Y, Imazu N, Moriyama T, Mohamed AN, Hirakawa K, Yamagata H, Okamoto Y, Kurahara K, Yada S, Harada A, Ago T.   +19 more
europepmc   +1 more source

Comparison of Clarus, Optos, and Heidelberg Systems for Geographic Atrophy Area Measurements. [PDF]

Ophthalmol Sci
Bogost J, Saunders T, Heathcote J, Pak JW, Lopez D, Froines C, Blodi B, Channa R, Schildroth K, Kurt K, Mititelu M, Stepien K, Chang JS, Altaweel M, Gottlieb J, Conlin K, Sabb P, Patel N, Domalpally A.   +18 more
europepmc   +1 more source

mSphere of Influence: How a gut microbiota study reshaped my thinking on tick-borne pathogens. [PDF]

mSphere
Wang X-R.
europepmc   +1 more source