Results 121 to 130 of about 522,358 (300)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Risk factor analysis and predictive model development for healthcare-associated infections post-coronary artery bypass grafting

Frontiers in Public Health
ObjectiveThis study aimed to analyze the risk factors associated with healthcare-associated infections (HAIs) in individuals who underwent post-coronary artery bypass grafting (CABG) and to develop a predictive model for infection risk assessment ...
Yan Liu, Lingbo Xue, Ping Jiang, Jiaojiao Shen, Xiao Peng, Xiaoqiang Yu   +5 more
doaj   +1 more source

Signal-Aligned Network Coding in K-User MIMO Interference Channels with Limited Receiver Cooperation

, 2018
In this paper, we propose a signal-aligned network coding (SNC) scheme for K-user time-varying multiple-input multiple-output (MIMO) interference channels with limited receiver cooperation.
Chan, Tse-Tin, Lok, Tat-Ming
core  

Position location system and method Patent [PDF]

, 1970
Position locating system for remote aircraft using voice communication and digital ...
Hollenbaugh, R. C., Laughlin, C. R., Jr.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Acute brain injury risk prediction models in venoarterial extracorporeal membrane oxygenation patients with tree-based machine learning: An Extracorporeal Life Support Organization Registry analysisCentral MessagePerspective

JTCVS Open
Objective: We aimed to determine if machine learning can predict acute brain injury and to identify modifiable risk factors for acute brain injury in patients receiving venoarterial extracorporeal membrane oxygenation.
Andrew Kalra, BS, Preetham Bachina, BS, Benjamin L. Shou, BS, Jaeho Hwang, MD, MPH, Meylakh Barshay, BS, Shreyas Kulkarni, BS, Isaac Sears, BS, Carsten Eickhoff, PhD, Christian A. Bermudez, MD, Daniel Brodie, MD, Corey E. Ventetuolo, MD, MS, Bo Soo Kim, MD, Glenn J.R. Whitman, MD, Adeel Abbasi, MD, ScM, Sung-Min Cho, DO, MHS, Bo Soo Kim, David Hager, Steven P. Keller, Errol L. Bush, R. Scott Stephens, Shivalika Khanduja, Jin Kook Kang, Ifeanyi David Chinedozi, Zachary Darby, Hannah J. Rando, Trish Brown, Jiah Kim, Christopher Wilcox, Albert Leng, Andrew Geeza, Armaan F. Akbar, Chengyuan Alex Feng, David Zhao, Marc Sussman, Pedro Alejandro Mendez-Tellez, Philip Sun, Karlo Capili, Ramon Riojas, Diane Alejo, Scott Stephen, Harry Flaster   +40 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Dynamic Modelling of Molten Salt Central Receiver Systems [PDF]

MATHMOD 2018 Extended Abstract Volume, 2018
Robert Flesch, Daniel Maldonado, Peter Schwarzbözl   +2 more
openaire   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source