Results 201 to 210 of about 522,358 (300)

Modelling strategies for porous structures as solar receivers in central receiver systems: A review

An international effort is being made to contribute to greener electricity production. Concentrated Solar Power (CSP) has emerged as the favourite candidate due to the advantages associated with it such as dispatchability, maturity and scalability. Particular interest is raised by Central Receiver Systems (CRSs) due to their ability to work at higher ...
AVILA-MARIN, ANTONIO, FERNANDEZ-RECHE, JESUS, Martínez-Tarifa, Maria Adela   +2 more
openaire   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effects of acid mine drainage from collapsed tailings dam on Zambia's human riparian communities: a fuzzy cognitive model perspective. [PDF]

Sci Rep
Nyirenda VR, Chama L, Phiri D, Musuka CG, Simuchimba G, Chibesa M, Simwanda M, Siamujompa M, Kasubika R, Kapembwa S, Siachoono S, Lwali AC, Namukonde N, Nyirenda W, Chunda-Mwango N, Kikamba E, Phiri CJ, M'doma B, Nkhata BA, Mubemba B, Murayama Y.   +20 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

3D Urban Outdoor WiFi 7 Network Planning and Analysis Using Ray-Tracing and Machine Learning: Transformer-Based Surrogate Modeling for High-Resolution Digital Twin. [PDF]

Sensors (Basel)
Trînc EC, Ancuți C, Vesa A, Simu C, Niță VA, Stolojescu-Crişan C.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Serum Levels of Glutamatergic (GRIN1) and Purinergic (P2RX1/P2RY2) Receptors in Patients with Fibromyalgia. [PDF]

Int J Mol Sci
Dogan SC, Kaya GC, Tuncbilek Z, Atas M, Tas A.   +4 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Discriminative role of inflammatory indices in clinical response to ganglion impar blockade: A retrospective cohort study. [PDF]

Medicine (Baltimore)
Babaoglu G, Sabuncu U, Dadali S, Costu A, Akcaboy EY.   +4 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source