Results 171 to 180 of about 345,428 (274)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

A Dual-Sequence MRI-Based Radiomics Model for Predicting High-Intensity Focused Ultrasound Ablation Efficacy in Adenomyosis Treatment

International Journal of Women's Health
Mengmeng Sun,1,2,* Xinyi Deng,3,* Hui Xing,1,4 Rui Zhang,3 Bingbing Fu,1 Tao Ai,5 Fang Wang,6 Xuechun Wang,6 Lei Chen,6 Xiaogang Mao,1,4 Feng Wu3 1Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of
Sun M, Deng X, Xing H, Zhang R, Fu B, Ai T, Wang F, Wang X, Chen L, Mao X, Wu F   +10 more
doaj  

Development and evaluation of a predictive model for central precocious puberty in girls. [PDF]

Transl Pediatr
Wu Y, Xu C, Li J, Zhang D, Wu Y, Feng X, Wang H.   +6 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy

Therapeutics and Clinical Risk Management
Shi-Yuan Tian,1 Min-Jie Yu,2 Kefu Mei,1 Bing Xu,1 Lian-Chen Xiao,1 Hong-Bin Wen,1 Fu-Rong Shang1 1Department of Neurology, Xiangyang Central Hospital, Affiliated Hospital of  Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of ...
Tian SY, Yu MJ, Mei K, Xu B, Xiao LC, Wen HB, Shang FR   +6 more
doaj  

The value of intratumoral and peritumoral ultrasound radiomics in predicting lateral cervical lymph node metastasis in papillary thyroid carcinoma: a multicenter study of five hospitals. [PDF]

Gland Surg
Jin K, Cao LL, He NA, Ye L, Zhan XL, Jiang F, Wang JJ.   +6 more
europepmc   +1 more source

2D parallel optical interconnects between CMOS ICs [PDF]

, 2006
ANNEN, R, Baets, Roel, Bockstaele, Ronny, BOSSARD, M, De Wilde, Michiel, MARION, F, Rits, Olivier, Roelkens, Günther   +7 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Correlation between liver fat fraction measured by MRI IDEAL-IQ sequence and ALT, GGT, and AST in colorectal cancer patients after chemotherapy. [PDF]

BMC Gastroenterol
Wang Z, Wang Z, Han S, Wang E, Song P.
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source