Results 211 to 220 of about 345,428 (274)

Candidate blood biomarkers linked with feed intake efficiency and weight gain in sheep. [PDF]

Sci Rep
Osonowo O, Goldansaz SA, Lei Y, Gellatly D, Jawad H, Borzouie S, Markus S, Miar Y, Thompson S, Manafiazar G.   +9 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors. [PDF]

Nat Commun
Sánchez-Lanzas R, Jiménez-Pompa A, Smith E, Sumaria N, Barclay J, Kalampalika F, Pennington DJ, Efremova M, Ganuza M.   +8 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

ABCA4 Versus PRPH2-Associated Retinopathy: Clinical and Electrophysiological Findings. [PDF]

Invest Ophthalmol Vis Sci
Heath Jeffery RC, Thompson JA, Lo J, Vincent AL, Patil M, Bianco L, Battaglia Parodi M, Ziccardi L, Dell'Aquila C, Barbano L, Tang WC, Chan CM, Boon CJF, Hensman J, Chen TC, Lin CY, Chen PL, Vincent A, Tumber A, Heon E, Grigg JR, Jamieson RV, Cornish EE, Nash BM, Chou J, Lamey TM, McLenachan S, Roshandel D, Fujinami K, Chelva E, McLaren TL, Chen FK.   +31 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

MRI quantitative imaging biomarkers in differentiating brain parenchymal tuberculoma and lung cancer brain metastases. [PDF]

Eur J Med Res
Wang A, Qiu X, Chen Q, Qiu Y, Wang Y, Hu Y, Wang J, Zhan M, Zhu H.   +8 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

An integrative deep learning model based on dual-mode ultrasound for diagnosing gallbladder polyps. [PDF]

Insights Imaging
Tang C, Shi Y, Wang L, Zhao X, Li C, Guan P, Geng Z, Chen J, Yu Q, Wang W, Zhu XX, Yuan H.   +11 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source