Results 111 to 120 of about 62,239 (284)

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li   +4 more
wiley   +1 more source

Sequential occlusion of the branch retinal artery and branch retinal vein in a patient with hypertension: an interventional case report

open access: yesClinical Ophthalmology, 2014
Norio Okamoto, Chota Matsumoto, Yoshikazu Shimomura Department of Ophthalmology, Kinki University Faculty of Medicine, Osakasayama City, Osaka, Japan Background: There are some cases that reported central retinal vein occlusion accompanied by ciliary ...
Okamoto N, Matsumoto C, Shimomura Y
doaj  

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

open access: yesMacromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani   +6 more
wiley   +1 more source

One day wonder: Fast resolution of macular edema following intravitreal ranibizumab in retinal venous occlusions

open access: yesIndian Journal of Ophthalmology, 2013
Macular edema is a significant cause of vision loss in patients with central retinal vein occlusions and branch retinal vein occlusions. Vascular endothelial growth factor (VEGF) appears to be a key factor in the pathogenesis of this disease.
Lalit Verma   +3 more
doaj   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

open access: yesMed Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang   +13 more
wiley   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

open access: yesRheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen   +6 more
wiley   +1 more source

Venous oxygen saturation is reduced and variable in central retinal vein occlusion [PDF]

open access: bronze, 2015
Ümit Yolcu   +3 more
openalex   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

open access: yesSmall, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa   +4 more
wiley   +1 more source

A flexible arched artificial photoreceptor constructed by photodeformable liquid crystal polymers and its application in vision restoration

open access: yesSmart Molecules, EarlyView.
A flexible arched artificial photoreceptor with high stability and biocompatibility was fabricated by integrating liquid crystal polymers with polyvinylidene fluoride‐trifluoroethylene. This device exhibits robust photoelectric responses under low‐intensity illumination and demonstrates efficacy in restoring visual responses in blind rats following ...
Yumeng Jiang   +7 more
wiley   +1 more source

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