Results 41 to 50 of about 62,239 (284)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Treating macular edema following RVO [PDF]

, 2014
Retinal vein occlusion (RVO) affects 16 million people worldwide, usually the middle-aged or older. It is caused by thrombosis, the clogging of the retinal veins, which may occur in the four branch veins – branch vein retinal occlusion (BVRO), or in the ...
Hrytsay, T.
core  

Accidental intralenticular dexamethasone intravitreal implant with the resolution of macular oedema in central retinal vein occlusion [PDF]

, 2016
No abstract ...
Abdolrahimzadeh, Solmaz, Plateroti, ANDREA MARIA, Plateroti, Pasquale, Scarinci, Fabio   +3 more
core   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Central retinal vein occlusion caused by anomalous prepapillary venous loop

Journal of Clinical Ophthalmology and Research, 2021
We present a case of prepapillary venous loop complicated by central retinal vein occlusion (CRVO). A 56-year-old female reported to us with blurring of vision in the right eye, noticed 8 days ago.
Pradeep Gajanan Tekade, H N Ravishankar, Pradeep Sagar   +2 more
doaj   +1 more source

An eighteen-month follow-up study on the effects of intravitreal dexamethasone implant in diabetic macular edema refractory to anti-VEGF therapy [PDF]

, 2016
AIM: To evaluate the long-term efficacy and safety of dexamethasone implants in subjects affected by diabetic macular edema (DME) resistant to anti-vascular endothelial growth factor (VEGF) therapy. METHODS: Thirty-two DME patients were enrolled.
Carnovale, Anna, Mastromatteo, Alessandra, Mollicone, Antonella, Pacella, Elena, Pacella, Fernanda, Romano, Maria Rosaria, Tarquini, Giovanna, Turchetti, Paolo   +7 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

association oF systemic Diseases witH retinal vein occlusive Disease

Journal of Nepal Medical Association, 2006
Retinal vein occlusion (RVO) is the second commonest vascular disease of the eye, second only to Diabetic Retinopathy. The association of the retinal vein occlusion with other systemic disease likes hypertension, diabetes mellitus and others has been ...
Rajesh Kishor Shrestha, J K Shrestha, S Koirala, D N Shah   +3 more
doaj   +1 more source

Cavernous sinus thrombosis elicited by a central retinal vein venous stasis retinopathy [PDF]

, 2018
Background: Central retinal vein occlusion is a relatively common retinal disorder in the elderly, and those with cardiovascular or thrombophilic risk factors are at increased risk.
Abdo, German, Pournaras, Constantin, Stangos, Alexandros, Zaninetti, Marc   +3 more
core  

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source