Results 181 to 190 of about 6,588,200 (233)
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
S. Garg +4 more
wiley +1 more source
European Management Review, EarlyView.Abstract We examine how a single exploitative employer decision event, conceptualized as a shock, interacts with employees' accumulated perceived employer exploitation to amplify feelings of violation and influence adverse employee reactions. This interaction effect, and its boundary conditions, constitutes the primary theoretical contribution of the ...
Dorothea Roumpi +3 more
wiley +1 more source
The FEBS Journal, EarlyView.Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti +3 more
wiley +1 more source
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
The FEBS Journal, EarlyView.AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney +10 more
wiley +1 more source
TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
The FEBS Journal, EarlyView.This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source
Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader +2 more
wiley +1 more source
Journal of Oral Rehabilitation, EarlyView.In this randomized controlled trial, adding aerobic exercise or strength training to physical therapy improved outcomes in patients with temporomandibular disorders and nociplastic pain. Aerobic exercise produced greater reductions in pain and central sensitization‐related symptoms, whereas strength training improved trapezius muscle strength and long ...
Flora Dantony +8 more
wiley +1 more source
Journal of Oral Rehabilitation, EarlyView.Higher central sensitization‐related symptoms levels based on the Central Sensitization Inventory (CSI) predict greater psychological distress, sleep disturbance, autonomic dysfunction and reduced response to long‐term conservative treatment in temporomandibular disorders.
Seok Jin Lee +4 more
wiley +1 more source
Individual Differences in the Effects of Life Events on Personality Trait Change
Journal of Personality, EarlyView.ABSTRACT Objective To date, effects of life events on personality trait change have been unsystematic, tenuous, and difficult to replicate. We focus on individual differences in change processes following life events, which have been neglected in previous studies.
Lara Oeltjen, Christian Kandler
wiley +1 more source
Holding vs. Using Power: A Dyadic Study of Mediated Power and Responsible Supply Chains
Journal of Supply Chain Management, EarlyView.ABSTRACT Business organizations must (re‐)evaluate their supply chain practices to foster responsible relationships while adopting strategies to achieve sustainability. Understanding the dynamic interactions among supply chain members is essential for advancing responsible supply chain practices. The authors define responsible supply chain practices as
Ying Yang +3 more
wiley +1 more source