Results 61 to 70 of about 5,697,836 (398)

Ozone, carbon monoxide and nitrogen oxides time series at four alpine GAW mountain stations in central Europe

, 2010
. Long-term, ground based in-situ observations of ozone (O3) and its precursor gases nitrogen dioxide (NO2) and carbon monoxide (CO) from the four sites Hohenpeissenberg and Zugspitze (D), Sonnblick (A) and Jungfraujoch (CH) are presented for the period ...
S. Gilge, C. Plass-Duelmer, W. Fricke, A. Kaiser, L. Ries, B. Buchmann, M. Steinbacher   +6 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Experimental population suppression of Richardson's ground squirrels (Spermophilus richardsonii) in Alberta [PDF]

, 1972
Richardson's ground squirrel is one of the most economically harmful rodents in east central Alberta. In an effort to develop an effective, safe, economical and practical method of long-term population control over large areas, experimental field testing
Alsager, D. E.
core  

Warming of Central European lakes and their response to the 1980s climate regime shift

Climatic Change, 2017
Lake surface water temperatures (LSWTs) are sensitive to atmospheric warming and have previously been shown to respond to regional changes in the climate.
R. Woolway, M. Dokulil, W. Marszelewski, M. Schmid, D. Bouffard, Christopher J. Merchant   +5 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Multi-Dimensional Display of Wang’s Lymph Node Map Using Virtual Bronchoscopic Navigation System

Frontiers in Molecular Biosciences, 2021
Background: Transbronchial needle aspiration (TBNA) is a classical technique for diagnosing mediastinal-hilar lymph node enlargement. However, the diagnostic value of conventional TBNA (cTBNA) is limited in small lymph nodes.Methods: Here, we generated ...
Fen Lan, Yaling Yue, Hong Shen, Hui Shen, Hui Shen, Qiyuan Wang, Xiujing Yu, Laijuan Chen, Qin Li, Kopen Wang, Qinghua Liu, Yang Xia   +11 more
doaj   +1 more source

Spatial variability of precipitation regimes over Turkey [PDF]

, 2010
Turkish annual precipitation regimes are analysed to provide large-scale perspective and redefine precipitation regions. Monthly total precipitation data are employed for 107 stations (1963–2002).
Akçar N., Atalay I., Beler Baykal B., Bower D., David M. Hannah, Faize Sariş, Griffith D. A., Kadioglu M., Kadioglu M., Karaca M., Kostopoulou E., Kutiel H., Kutiel H., Sen Z., Spanos S., Tatli H., Türkes M., Türkes M., Türkes M., Warren J. Eastwood, Yarnal B.   +20 more
core   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Dynamic System Approach for Improved PM_2.5 Prediction in Taiwan

IEEE Access, 2020
This study presents two dynamic models, namely recurrent neural network and long short-term memory (LSTM) models, for predicting PM2.5 concentrations in Taiwan by using PM2.5 time series obtained at air quality monitoring stations and weather information
Larry Lin, Chih-Yuan Chen, Hsien-Yueh Yang, Zhezhuang Xu, Shih-Hau Fang   +4 more
doaj   +1 more source

Measuring the electric field of a cloud [PDF]

, 1973
Network of electric field measuring stations has been developed to assess lightning hazard of charged clouds.
Lovall, D. D., Wojtasinski, R. J.
core   +1 more source