Results 151 to 160 of about 200,011 (267)

Microsurgical obliteration of a high-flow intraorbital arteriovenous malformation fed by the ophthalmic artery: Illustrative case. [PDF]

Surg Neurol Int
Lame AA, Ruka ME, Kalefi TF, Disha KH, Xhumari AA.   +4 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Sustainable Healthcare: A Perspective on the Current Landscape, Frameworks, Barriers, and Implementation Model in a Quaternary Hospital System. [PDF]

Int J Environ Res Public Health
Tuyishime H, Lin C, Chawla A, Khoo B, Shea KG.   +4 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Repositioning Primary Health Care in Sierra Leone: From Geographic Access to Effective Coverage. [PDF]

Ann Glob Health
Vandi M, Koroma JM, Kabba MS.
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Assessing spatial equity in integrated health care facilities for older adults: a case study in the metropolis of Guangzhou, China. [PDF]

Front Public Health
Liu Y, Ye C, Wu Y, Fang K, Mi J.
europepmc   +1 more source

Laser Central Supply System in Kitasato University Higashi Hospital

THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE, 1987
Yamao, Tetsuhiko, Shimao, Hitoshi, Mieno, Hiroyoshi, Kuranami, Masaru, Hiki, Yoshiki   +4 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Regional inequities in myocardial infarction burden in Brazil's public healthcare system. [PDF]

Arch Public Health
Arzumanov SA, Stephanus AD, Barreto J, Carvalho LSF, Sposito AC, Campos-Staffico AM.   +5 more
europepmc   +1 more source