Results 91 to 100 of about 877,000 (269)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Effect of foot type on electromyography characteristics and synergy of lower limb muscles during running

Scientific Reports
The foot structure is associated with different running mechanics. The central nervous system is responsible for using the muscles through synergies during locomotion.
Behrouz Hajilou, Hamed Esmaeili, Mehrdad Anbarian   +2 more
doaj   +1 more source

Topological optimisation and laser additive manufacturing of force-direction-sensitive NiTi porous structures with large deformation recovery behaviour

Virtual and Physical Prototyping
Optimising the cell type and configuration is a key approach for overcoming stress concentration and irreversible deformation in lightweight lattice structures with high strength.
Xin Liu, Dongdong Gu, Luhao Yuan, Xinyu Shi, Keyu Shi, Jianfeng Sun, Wenxin Chen, Jie Wang   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural basis of fatty acid activation and transport by human FATP2

Nature Communications
Fatty acid transport proteins (FATPs) are responsible for efficient uptake of fatty acids (FAs), essential biomolecules that play critical roles in development and growth.
Ao Li, Junhui Shi, Xiaoyan Xu, Yu Yang, Shan Feng, Dan Ma   +5 more
doaj   +1 more source

Mixed exponential statistical structures and their approximation operators

Математичні Студії
The paper examines the construction and analysis of a new class of mixed exponential statistical structures that combine the properties of stochastic models and linear positive operators.
O. Volkov, Yu. Volkov, N. Voinalovych
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Impact of the 3-D structure on the photovoltaic potential in Urban areas

Frontiers in Energy Research
IntroductionWith the acceleration of urbanization and the continuous growth in energy demand, distributed photovoltaic (PV) systems have attracted increasing attention as a sustainable energy solution.
Hu Shouchao, Li Dong, Chang Zengliang, Tong Hongju, Gao Xingguo, Cao Qian   +5 more
doaj   +1 more source