Results 161 to 170 of about 169,804 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Identity centrality as a double-edged sword: mental health mechanisms among lesbian/gay and bisexual university students in China. [PDF]

Front Psychol
Zhang S, Yao X, Tan K, Wei C.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Lower resting-state EEG mean eigenvector centrality is associated with higher math anxiety. [PDF]

Front Hum Neurosci
Pavlova A, Adamovich T, Malykh S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Centrality and content creation in networks the case of German Wikipedia

, 2012
When contributing content on large online platforms, producers of user-generated content have to decide where to contribute. On a complex and dynamic platform like Wikipedia, this decision is expected to depend on the way the content is organized.
Giorgidze, George, Kummer, Michael E., Halatchliyski, Iassen, Saam, Marianne 1976-   +3 more
core  

Survey-calibrated agent-based modeling of peer targeting for promoting physical activity among adolescents. [PDF]

Front Public Health
Long W, Zheng B, Wu Z, Qian H, Zou Y, Tan J, Wang Y.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Key Players and Key Groups in Teams [PDF]

This paper contributes to the literature on centrality measures in economics by defining a team game and identifying the key players in the game. As an illustration of the theory we create a unique data set from the UEFA Euro 2008 tournament.
Emre Unlu, Sudipta Sarangi
core  

Network analysis of psychological capital: mapping interconnected dynamics in teacher wellbeing and professional commitment. [PDF]

Front Psychol
Yanran Z, Ishak Z, Bicheng D.
europepmc   +1 more source