Results 271 to 280 of about 4,708,577 (333)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Religiously observant faculty, staff, and learners. [PDF]

CMAJ
Chaikof M, Shah P, Najeeb U.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Nii Kandis (Knowing Myself): Finding a Sacred Home at Anishnawbe Health Toronto Through Spirit-Based Healing. [PDF]

Int J Environ Res Public Health
Reeves A, Toronto AH, Beaulieu T, Jordon K.   +3 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

PRHOCARER study: protocol for a multicentre, convergent, mixed-methods trial assessing the effectiveness of pulmonary rehabilitation programmes and the needs of informal carers of people with chronic respiratory diseases. [PDF]

BMJ Open Respir Res
Robic M, Grosbois JM, Racodon M, Le Rouzic O, Ramon P, Masson N, Fabre C, Gephine S.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

New pathways with high-sensitivity cardiac troponin testing at the point of care in the ambulance and primary care. [PDF]

Eur Heart J Acute Cardiovasc Care
Johannessen TR, Body R, Mair J, Mills NL, Cullen L, Study Group on Biomarkers of the ESC Association for Acute Cardiovascular Care .   +5 more
europepmc   +1 more source

A national strategy for a canadian limb loss and limb difference registry. [PDF]

Can Prosthet Orthot J
Mayo AL, Hitzig SL, Zidarov D, MacKay C, Kaufman KR, Noonan VK, Andrysek J, Azhari F, Best KL, Robert M, Dilkas S, Campbell J, Eshraghi A, Dudek N, Lemaire ED, Guilcher SJT, Nowrouzi-Kia B, Habra N, Jean S, Hebert JS, Dobrowolski S, Hoosein PE, Payne MW, King S, Underwood H, Pousett B, Totosy de Zepetnek JO, Zucker-Levin A, Saporta A, Wong K, Glasford S, Hedlund S, Ellis J, Wong A, Yang B, Roddick K, Raschke SU, Journeay WS, Laakso L, Kok B, Moschiar Almeida B, Richardson A, Aternali A, Tiessen J, Miller WC.   +44 more
europepmc   +1 more source