Results 111 to 120 of about 103,967,562 (276)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Interferencias oclusales en pacientes de alta de Ortodoncia Occlusal interferences in patients discharged from the Orthodontics Service

Revista Cubana de Estomatología, 2005
Se realizó un estudio de 20 pacientes egresados del Servicio de Ortodoncia de la Facultad de Estomatología de Ciudad de La Habana, cuyas edades no excedieran los 30 años, con el objetivo de analizar la frecuencia de las interferencias oclusales, teniendo
.Gladys Otaño Laffitte, Maiyelín Llanes Rodríguez, Lucía Delgado Carrera, Ileana Grau, Rolando Castillo   +4 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Customer-centric sales organizations

, 2019
Selling practices have shifted from being product- to customer-centric in nature. Moreover, the adoption of digital technologies has significantly reshaped the business environment.
Weaven, Scott, Thaichon, Paramaporn
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Visible light communications in heterogeneous networks: pave the way for user-centric design

, 2015
At the time of writing, there is substantial research interest in the subject of Visible Light Communications (VLC) owing to its capability of offering significant traffic offloading potential in highly crowded Radio Frequency (RF) scenarios.
Wang, Jiaheng, Wang, Zhaocheng, Xu, Zhengyuan, Zhao, Chunming, Zhang, Rong, Hanzo, Lajos   +5 more
core   +1 more source

Prevalence of Interceptive Contacts in Centric Relation in Complete Denture Wearers

Frontiers in Dentistry, 2008
Objective: Interceptive contacts in complete denture cause some side effects. To our knowledge, however, no comprehensive reports exist on the prevalence of interceptive contacts after complete denture placement.
P. Atashrazm, MH. Dashti, MR. Mobeinie   +2 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source