Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Digital Recordings of Centric Relation Using Conventional and Digital Techniques: Patient-Reported Outcome Measures (PROMs). [PDF]
J Clin MedKoçar ES, Akça K.
europepmc +1 more source
[Research progress on the relationship between centric relation and orthodontic treatment]. [PDF]
Hua Xi Kou Qiang Yi Xue Za Zhi, 2019 Jing D, Shen Y, Yang P, Zhao ZH.
europepmc +1 more source
Nih and tuh as spatial deixis in imagined interaction [PDF]
, 2014 DJENAR, Dwi Noverini
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Reproducibility of Centric Relation Techniques by means of Condyle Position Analysis. [PDF]
Acta Stomatol Croat, 2017 Galeković NH +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Anterior temporalis and masseter muscle activity with different centric relation locating methods: A randomized cross-over trial. [PDF]
Sci RepNofal AT, Kois JC, Elbasty RS, Zaki AA.
europepmc +1 more source
Three-dimensional assessment of condylar position following orthognathic surgery using the centric relation bite and the ramal reference line: A retrospective clinical study. [PDF]
Medicine (Baltimore), 2019 Lee CH +5 more
europepmc +1 more source