Results 141 to 150 of about 74,772 (299)

Structures of the Temporomandibular Joint That Pertain to Centric Relation

, 1961
The inconsistencies observed between reports in the literature and personal clinical experience as a resident in prosthodontics, prompted a critical survey of the anatomic basis of centric relation.
Boucher, Louis J.
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Roadmap on Data-Centric Materials Science

Science is and always has been based on data, but the terms ‘data-centric’ and the ‘4th paradigm’ of materials research indicate a radical change in how information is retrieved, handled and research is performed.
Ralph, Ernstorfer, Christoph, Freysoldt, Matthias, Scheffler, Annette, Trunschke, Jörg, Neugebauer, Zongrui , Pei, Mohammad S. , Khorrami, Peter, Fratzl, Gerhard, Dehm, Yi, Yao, Andreas, Marek, Anton, Gladyshev, Ulf, Saalmann, Lara, Kabalan, Sajal K. , Giri, Pawan, Goyal, Zhongwei , Lu, Marcel, Schloz, R. Patrick , Xian, Lucas, Foppa, Simon, Teshuva, Kurt, Kremer, Thomas A. R. , Purcell, Jan-Michael , Rost, Sebastian, Eibl, Igor, Kowalec, Felix, Luong, Andreas, Leitherer, Volker, Blum, Mario, Boley, Ye, Wei, Baptiste, Gault, Peter, Benner, Luca M., Ghiringhelli, Florian, Merz, Jason, Hattrick-Simpers, Markus, Rampp, Thomas, Kosch, Luigi , Sbailò, Mariana, Rossi, Daniel F. , Schmidt, Meng, Zhao, Tristan, Bereau, Petr, Karpov, Stefan, Bauer, Christian, Carbogno, Jaber R. , Mianroodi, Dierk, Raabe, James, Saal, Junqi, Yin, Markus, Scheidgen, Gerhard , Weikum, Kasturi Narasimha , Sasidhar, Alaukik, Saxena, C. Richard A. , Catlow, Christian H. , Liebscher, Ádám, Fekete, Yue, Li, Sebastian, Kokott, Christoph, Koch, Andrew J. , Logsdail   +60 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Reliability of a measuring-procedure to locate a muscle-determined centric relation position.

, 2004
Item does not contain fulltextAlthough reproducibility of centric relation position, determined with an anterior deprogramming device, a leaf gauge, is widely accepted among clinicians, data confirming statistical evidence are lacking in the current ...
Zonnenberg, A.J.J., Mulder, J., Cabri, R., Sulkers, H.R.   +3 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source