Results 211 to 220 of about 276,069 (308)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Centric stabilization occlusal splints vs. other conservative therapies in the management of temporomandibular disorders: a systematic review and meta-analysis. [PDF]

Saudi Dent J
Gupta AK, Singh RK, Narula V.
europepmc   +1 more source

Assessment of the Severity of COVID-19 on the Basis of Examination and Laboratory Diagnostics in Relation to Computed Tomography Imagery of Patients Hospitalised Due to COVID-19—Single-Centre Study [PDF]

Tomasz Ilczak, Szymon Skoczyński, Ewa Ocłoń, Mirosław Kucharski, Tomasz Strejczyk, Marta Jagosz, Antonina Jedynak, Michał Wita, Michał Ćwiertnia, Marek Jędrzejek, Mieczysław Dutka, Wioletta Waksmańska, Rafał Bobiński, Roch Pakuła, Marek Kawecki, Paweł Kukla, Szymon Białka   +16 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Influence of Maxillofacial Morphology on Temporomandibular Joint Degenerative Alterations and Condyle Position Assessed by CBCT in Class II Malocclusion Adult Patients-A Cross-Sectional Study. [PDF]

J Clin Med
Dygas S, Szarmach I, Radej I, Chaqués-Asensi J.   +3 more
europepmc   +1 more source

Off-centre ignition of sub-Chandrasekhar white dwarfs does not resolve the tension with the observed t0–MNi56 relation of type Ia supernovae

Eden Schinasi-Lemberg, Doron Kushnir
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Response to: Criticism of the systematic Review (SR) ‘centric relation-intercuspal position discrepancy and its relationship with temporomandibular disorders’

, 2019
Antonio Jiménez‐Silva, Julio Tobar‐Reyes, Sheilah Vivanco-Coke, Eduardo Pastén-Castro, Raúl Frugone-Zambra, Hernán Palomino‐Montenegro   +5 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Sheldon Friel Memorial Lecture 2025-Orthodontics and Temporomandibular Disorders: evolving views on risk factors, diagnosis, and management. [PDF]

Eur J Orthod
Michelotti A.
europepmc   +1 more source