Results 181 to 190 of about 19,250,496 (285)

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

open access: yesAdvanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang   +4 more
wiley   +1 more source

FIELD AND CENTRIFUGE MODEL TEST ON HEAVY TAMPING

open access: yesDoboku Gakkai Ronbunshu, 1993
Naotoshi TAKADA   +3 more
openaire   +2 more sources

Enhanced Acoustic Adhesion Enabling Agile and Small Wall‐Climbing Robot Design With Anisotropic Origami Structure

open access: yesAdvanced Science, EarlyView.
This 28 g robot incorporates innovative ring structures and anisotropic origami springs to achieve high speeds and exceptional load capacity. It successfully carries a 100 g payload while ascending walls or ceilings at speeds of up to 8 and 20 cm/s, demonstrating enhanced adhesion and maneuverability over current climbing robots.
Xinxian Chen   +5 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

open access: yesAdvanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu   +6 more
wiley   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

open access: yesAdvanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang   +10 more
wiley   +1 more source

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

open access: yesAdvanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou   +3 more
wiley   +1 more source

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