Results 171 to 180 of about 127,479 (265)

Experimental study on the effect of warm acupuncture on the healing of bone nonunion in rats. [PDF]

J Chin Med Assoc
Mei Y, Song C, Gao Y, Zhou D, Gao S, Cheng K, Guo D, Cai W, Yu F, Liu Z.   +9 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Protocol to generate endothelial cell-specific knockout mouse models using Cas9/Cdh5-Cre mice coupled with sgRNA. [PDF]

STAR Protoc
Wang DM, Tiruppathi C.
europepmc   +1 more source

Centrifuge model tests on bearing capacity of clay

Centrifuge model tests on bearing capacity of clay
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Effects of Temperature and Exposure Duration on Energy Substances and Antioxidant Enzymes in <i>Riptortus pedestris</i> (Hemiptera: Alydidae). [PDF]

Insects
Song K, Zhang L, Li X, Zhao S, Qu W, Xu ML, Yang J, Gao Y.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Lipid Analysis in Live <i>Caenorhabditis elegans</i> Using Solution-State NMR Spectroscopy. [PDF]

Bio Protoc
Guastaferri FV, Delprato CB, Cravero BH, Prez G, De Mendoza D, Binolfi A.   +5 more
europepmc   +1 more source

FIELD AND CENTRIFUGE MODEL TEST ON HEAVY TAMPING

Doboku Gakkai Ronbunshu, 1993
Naotoshi TAKADA, Akihiko OSHIMA, Atsushi WATANABE, Michiharu IKEDA   +3 more
openaire   +2 more sources