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Crystallization Kinetics of Cephalexin Monohydrate in the Presence of Cephalexin Precursors
Crystal Growth & Design, 2019 The solubility and crystallization kinetics of cephalexin monohydrate, an important β-lactam antibiotic, are reported for the first time for an aqueous solution. The nucleation and growth kinetics are determined with online process analytical technologies (PAT) and offline image analysis to support implementation of a continuous process. Effects of two
Matthew A. McDonald +4 more
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Enzymatic production of cephalexin
Enzyme and Microbial Technology, 1994Enzymatic production of cephalexin using immobilized penicillin G acylase was studied. The factors that affect the conversion of 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) to cephalexin, such as pH; temperature; concentrations of 7-ADCA, D(-)-phenylglycine methyl ester (PGME), and immobilized penicillin G acylase (IMPGA); time; and molar ratios ...
exaly +3 more sources
Medical Clinics of North America, 1970
Cephalexin (Ceporex - Glaxo; Keflex - Lilly), is a new antibiotic derived from cephalosporin C. It is a derivative of 7-aminocephalosporanic acid closely resembling the penicillin analogue, ampicillin, and is the first of the cephalosporins that is active by mouth.
R S, Griffith, H R, Black
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Cephalexin (Ceporex - Glaxo; Keflex - Lilly), is a new antibiotic derived from cephalosporin C. It is a derivative of 7-aminocephalosporanic acid closely resembling the penicillin analogue, ampicillin, and is the first of the cephalosporins that is active by mouth.
R S, Griffith, H R, Black
+6 more sources
Enzymatic biosynthesis of cephalexin
Biotechnology and Bioengineering, 1980AbstractThe reaction kinetics of the enzymatic of cephalexin from 7‐aminodea‐cetoxy cephalosporanic acid and phenylglycine methylester was studied using the synthesizing enzyme obtained from Xanthomonas citri. The activation energy, Km value for 7‐aminodeacetoxy cephalosporanic acid and phenylglycine methylester, and Ki value for phenylglycine ...
D K, Rhee +4 more
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