Results 241 to 250 of about 159,979 (309)

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Plasma Lipidomic Signatures Across the Healthy-Pre-COPD-COPD Continuum Identified by Machine Learning. [PDF]

Int J Chron Obstruct Pulmon Dis
Xing Y, Yu G, Tian Q, Zhang T, Li D, Guo Y, Luo X, Li W, Liu X, Xu J, Li J.   +10 more
europepmc   +1 more source

Van der Waals Gap‐Confined Molecular Engineering of MoS2 for Selectivity‐Enhanced and Humidity‐Tolerant Gas Sensing

Advanced Science, EarlyView.
Molecular confinement within van der Waals gaps of MoS2 is established as a powerful design strategy for selective and stable chemical sensing. Ethanol‐confined films simultaneously tune electronic doping, surface wettability, and sulfur vacancy configurations, suppressing water interference while enhancing NO2 adsorption.
Jae Hyung Shim, Gwang Su Kim, Tae Hyung Lee, Jaeho Lee, Su‐Yeon Joung, Jung Hoon Kang, Jin Seok Kim, Jung‐Won An, Chong‐Yun Kang, Ho Won Jang, Jungwon Park, Ji‐Soo Jang, Chul‐Ho Lee   +12 more
wiley   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Spatial and single-cell dissection of medulloblastoma identifies developmental hierarchies and a prognostic PPIA-BSG tumor-immune axis. [PDF]

J Transl Med
Chen M, Duan B, Zhang J, Daniels C, Hu C, Yuan J, Guo J, Taylor MD, Shi X, Zhang L, Li D, Sun T.   +11 more
europepmc   +1 more source

Skin Lipid Dysregulation in Atopic Dermatitis and Related Inflammatory Skin Diseases. [PDF]

Allergy Asthma Immunol Res
Kim HB, Park J, Lim CS, Um JY, Chung BY, Park CW, Lee DK, Kim HO.   +7 more
europepmc   +1 more source

Neutrophil extracellular traps and parasite load are associated with dermal matrix remodeling in Leishmania braziliensis infection. [PDF]

Rev Soc Bras Med Trop
Silva GPD, Silva JMD, Doneda DL, Ávila ETP, Toso VD, Hueb M, Lima TDR, Damazo AS.   +7 more
europepmc   +1 more source

Noninvasive decoding of typed sentences from human brain activity. [PDF]

Nat Neurosci
Lévy J, Zhang M, Pinet S, Rapin J, Banville H, d'Ascoli S, King JR.   +6 more
europepmc   +1 more source