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Neurodegenerative Cerebellar Ataxia
Continuum, 2022Neurodegenerative cerebellar ataxia is a diverse collection of diseases that are unified by gait and balance abnormalities, appendicular incoordination, and abnormalities of eye movement and speech. The differential diagnosis is broad, ranging from paraneoplastic syndromes that progress quite rapidly to unidentified genetic disorders that progress ...
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Cerebellar Stimulation in Ataxia
The Cerebellum, 2011The cerebellum plays an important role in movement execution and motor control by modulation of the primary motor cortex (M1) through cerebello-thalamo-cortical connections. Transcranial magnetic stimulation (TMS) allows direct investigations of neural networks by stimulating neural structures in humans noninvasively.
Stefan Jun, Groiss, Yoshikazu, Ugawa
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Cerebellar and Afferent Ataxias
Continuum, 2013Ataxia is the predominant manifestation of many acquired and inherited neurologic disorders affecting the cerebellum, its connections, and the afferent proprioceptive pathways. This article reviews the phenomenology and etiologies of cerebellar and afferent ataxias and provides indications for a rational approach to diagnosis and management.The ...
Pandolfo, Massimo, Manto, Mario
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Non-cerebellar ataxias: posterior column-like ataxia and cerebellar-like ataxia
Rinsho Shinkeigaku, 2023Ataxia is not only due to cerebellar lesions, but also due to non-cerebellar lesions such as those in the brain, spinal cord, dorsal root (DR), peripheral nerve. In this article, optic ataxia is excluded and 'vestibular ataxia' is briefly referred. Non-cerebellar ataxias are generically called sensory ataxia or posterior column ataxia.
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Cerebellar Ataxia in the Elderly
Journal of the Royal Society of Medicine, 1992In a retrospective study of 624 elderly patients referred with falls and gait disorders, 45 patients were found to have ataxia. Cerebrovascular diseases were the most common underlying cause of ataxia (15 patients, 37%). Nine patients had hereditary/degenerative cerebellar ataxia. History suggesting alcohol as an underlying cause was established in two
A F, Safe, S, Cooper, A C, Windsor
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2018
The cerebellum plays an integral role in the control of limb and ocular movements, balance, and walking. Cerebellar disorders may be classified as sporadic or hereditary with clinical presentation varying with the extent and site of cerebellar damage and extracerebellar signs.
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The cerebellum plays an integral role in the control of limb and ocular movements, balance, and walking. Cerebellar disorders may be classified as sporadic or hereditary with clinical presentation varying with the extent and site of cerebellar damage and extracerebellar signs.
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Cerebellar stimulation in acute cerebellar ataxia
Clinical Neurophysiology, 2001To report follow-up studies of cerebellar stimulation in patients with acute cerebellar ataxia (ACA).We studied two patients with ACA. One patient also had decreased deep sensations in the feet due to combined diseases such as diabetic polyneuropathy and lumbosacral radiculopathies. We applied the technique of electrical stimulation over the cerebellum
K, Matsunaga +3 more
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Proceedings of the Royal Society of Medicine, 2010
AbstractDisease processes affecting the cerebellum and its connections, such as can occur in multiple sclerosis, often lead to lack of motor coordination, postural tremor, and tremor on directed movement; these symptoms can be difficult to treat. The cerebellum generates oscillations over a range of frequencies (beta, gamma, very fast) and some of ...
Roger D. Roger, Miles A. Whittington
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AbstractDisease processes affecting the cerebellum and its connections, such as can occur in multiple sclerosis, often lead to lack of motor coordination, postural tremor, and tremor on directed movement; these symptoms can be difficult to treat. The cerebellum generates oscillations over a range of frequencies (beta, gamma, very fast) and some of ...
Roger D. Roger, Miles A. Whittington
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Current Drug Research Reviews
Abstract: Brain-derived neurotrophic factor (BDNF) has been proposed as a treatment for neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its main receptor, TrkB, are often diminished relative to controls, thereby serving as replacement therapy.
Robert Lalonde +2 more
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Abstract: Brain-derived neurotrophic factor (BDNF) has been proposed as a treatment for neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its main receptor, TrkB, are often diminished relative to controls, thereby serving as replacement therapy.
Robert Lalonde +2 more
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Seminars in Neurology, 2014
This review broadly covers the commoner genetic ataxias, concentrating on their clinical features. Over the last two decades there has been a potentially bewildering profusion of newly described genetic ataxias. However, at least half of dominant ataxias (SCAs) are caused by (CAG)n repeat expansions resulting in expanded polyglutamine tracts (SCAs 1, 2,
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This review broadly covers the commoner genetic ataxias, concentrating on their clinical features. Over the last two decades there has been a potentially bewildering profusion of newly described genetic ataxias. However, at least half of dominant ataxias (SCAs) are caused by (CAG)n repeat expansions resulting in expanded polyglutamine tracts (SCAs 1, 2,
openaire +2 more sources