Results 261 to 270 of about 81,081 (302)
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Current Opinion in Neurology, 2020
Purpose of review Providing an update on the pathophysiology, cause, diagnosis and treatment of cerebellar ataxias. This is a group of sporadic or inherited disorders with heterogeneous clinical presentation and notorious impact on activities of daily life in many cases.
Mario, Manto +3 more
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Purpose of review Providing an update on the pathophysiology, cause, diagnosis and treatment of cerebellar ataxias. This is a group of sporadic or inherited disorders with heterogeneous clinical presentation and notorious impact on activities of daily life in many cases.
Mario, Manto +3 more
openaire +2 more sources
Capecitabine-associated cerebellar ataxia
American Journal of Health-System Pharmacy, 2008A case of capecitabine-associated cerebellar ataxia is presented.A 65-year-old white woman with stage IV colorectal cancer with liver metastasis was started on a chemotherapy regimen of capecitabine, oxaliplatin, and bevacizumab, given every three weeks. She tolerated the first two treatment cycles fairly well without major toxicities. The capecitabine
Masha S H, Lam +2 more
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Treatment of Cerebellar Ataxia
Neurodegenerative Disease Management, 2014Symptoms of cerebellar degeneration include ataxia or wide-based gait, visual and speech dysfunction, dysmetria, and dyscoordination. The etiology of cerebellar degeneration is vast and often complex, and requires neuroimaging, lab assessments, and a thorough family history to delineate its cause.
Tracy M, Jones +3 more
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Autosomal dominant cerebellar ataxias
Revue Neurologique, 2011Cerebellar ataxias with autosomal dominant transmission (ADCA) are far rarer than sporadic cases of cerebellar ataxia. The identification of genes involved in dominant forms has confirmed the genetic heterogeneity of these conditions and of the underlying mechanisms and pathways.
C, Marelli +4 more
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Autosomal-dominant cerebellar ataxias
2018Spinocerebellar ataxias (SCAs) are a genetically diverse group of dominantly inherited disorders that share clinical features that result from dysfunction and degeneration of the cerebellum and its associated pathways. Although nearly 40 genes are currently recognized to result in SCA, shared mechanisms for disease pathogenesis exist among subsets of ...
Andrew, Mundwiler, Vikram G, Shakkottai
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Primary progressive cerebellar ataxia
Neuroradiology, 1989Thirty-two patients with primary progressive cerebellar ataxia were studied using MRI. This technique is better than CT in demonstrating atrophy of cerebellar structures as well as of brainstem and spinal cord. The differential diagnosis from other diseases particularly with multiple sclerosis is easier.
G B, Bradac +4 more
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1997
Abstract Major inroads have now been made by molecular geneticists into the differentiation of the many syndromes of cerebellar ataxia. In general, it is still useful to use age of onset and associated features as a starting point. Congenital onset: cerebellar hypoplasia recessive; cerebellar hypoplasia dominant; cerebellar hypoplasia ...
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Abstract Major inroads have now been made by molecular geneticists into the differentiation of the many syndromes of cerebellar ataxia. In general, it is still useful to use age of onset and associated features as a starting point. Congenital onset: cerebellar hypoplasia recessive; cerebellar hypoplasia dominant; cerebellar hypoplasia ...
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2016
Abstract This chapter deals with disorders of the cerebellum and its connections. These conditions may be identified by the mode of onset—whether acute, subacute, chronic, or episodic. The chronic ataxias are inherited in various patterns: autosomal dominant; autosomal recessive; X-linked.
Christopher H. Hawkes +2 more
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Abstract This chapter deals with disorders of the cerebellum and its connections. These conditions may be identified by the mode of onset—whether acute, subacute, chronic, or episodic. The chronic ataxias are inherited in various patterns: autosomal dominant; autosomal recessive; X-linked.
Christopher H. Hawkes +2 more
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Cerebellar and Afferent Ataxias
Continuum, 2013Ataxia is the predominant manifestation of many acquired and inherited neurologic disorders affecting the cerebellum, its connections, and the afferent proprioceptive pathways. This article reviews the phenomenology and etiologies of cerebellar and afferent ataxias and provides indications for a rational approach to diagnosis and management.The ...
Pandolfo, Massimo, Manto, Mario
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Abstract This chapter deals with disorders of the cerebellum and its connections. These conditions may be identified by the pattern of onset—whether acute, chronic, or episodic. Genetic ataxias are inherited in various patterns: autosomal dominant, autosomal recessive, X-linked. Some episodic ataxias have variable inheritance.
Christopher H. Hawkes +2 more
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Christopher H. Hawkes +2 more
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