Results 91 to 100 of about 91,745 (210)
Annals of Neurology, EarlyView.Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto +12 more
wiley +1 more source
Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression
Annals of Neurology, EarlyView.Objective Magnetic resonance imaging (MRI)‐visible enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (SVD) and aging, processes implicated in both neurodegenerative and cerebrovascular pathologies. However, longitudinal positron emission tomography (PET) studies examining PVS as a mechanism underlying Alzheimer's disease ...
Audrey Low +11 more
wiley +1 more source
Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System
Annals of Neurology, EarlyView.Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti +17 more
wiley +1 more source
Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex. [PDF]
Cells, 2023 Santana-Bejarano MB +7 more
europepmc +1 more source
Annals of Neurology, EarlyView.Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl +10 more
wiley +1 more source
Entrainment of Cerebellar Nuclear Cells via AC Stimulation of the Cerebellar Cortex. [PDF]
Int IEEE EMBS Conf Neural Eng, 2023 Kang Q, Lang E, Sahin M.
europepmc +1 more source
The Anatomical Record, EarlyView.Abstract A recent debate has emerged between Caspar et al. (2024) and Herculano‐Houzel (2023) on inferring extinct dinosaur cognition by estimating brain neuron counts. While thought‐provoking, the discussion largely overlooks the function of cognition, as well as partly neglects the difficulties involved in estimating neuron numbers, which according ...
Thomas Rejsenhus Jensen +7 more
wiley +1 more source
Neural correlates of cocaine-induced conditioned place preference in the posterior cerebellar cortex. [PDF]
Front Behav Neurosci, 2023 Rodríguez-Borillo O +7 more
europepmc +1 more source
The Anatomical Record, EarlyView.Abstract Last year, we challenged the view that large‐bodied theropod dinosaurs such as Tyrannosaurus rex resembled primates in cognition and behavior, a proposition made by Herculano‐Houzel in 2023. More recently, Jensen et al. have criticized our work on this topic, raising methodological and conceptual issues.
Kai R. Caspar +5 more
wiley +1 more source
Multiunit Recording of Cerebellar Cortex in Autistic Male Rats during Social Interaction in Enriched Environments. [PDF]
NeuroSci, 2023 Cruz-Magos OE +7 more
europepmc +1 more source