Results 101 to 110 of about 17,546 (218)
Abstract INTRODUCTION Visit‐to‐visit blood pressure variability (BPV) may be associated with cognitive decline beyond mean blood pressure (BP), but its relevance across treatment contexts remains uncertain. METHODS We pooled individual‐participant data from Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD‐MIND) and Systolic ...
Yue Qiao +4 more
wiley +1 more source
Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease
Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage‐informed framework in which rapid eye movement (REM) sleep‐related respiratory events amplify vascular ...
Destiny E. Berisha +2 more
wiley +1 more source
A Closed‐Loop Cardiovascular Model of the Supine‐To‐Stand Manoeuvre: Implications for Falls
Continuous beat‐to‐beat modeling of supine‐to‐stand hemodynamics in older adults reproduces orthostatic responses and reveals differences in baroreflex, muscle‐pressure, and blood volume in those with a fall history, providing a basis for mechanistic phenotyping to enhance orthostatic hypotension diagnosis.
Joeri A. van de Sande +7 more
wiley +1 more source
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy +8 more
wiley +1 more source
Exercise training and dynamic cerebral autoregulation: Is adaptation possible?
Experimental Physiology, EarlyView.
Patrice Brassard
wiley +1 more source
Approximately 10%–30% of elderly patients develop cognitive decline after surgery. How brain regions coordinate cellular networks to mediate this remains unclear. Anesthesia/surgery induces Piezo1 in hippocampal endothelial cells of aged mice. Endothelial Piezo1 deletion restores BBB integrity and improves cognition.
Yong Qiu +13 more
wiley +1 more source
Integrative regulation of cerebral blood flow in response to exercise and environmental extremes
Experimental Physiology, EarlyView.
Shigehiko Ogoh, Damian M. Bailey
wiley +1 more source
ABSTRACT Introduction Severe brain injury has been reported following fetoscopic laser ablation (FLA) for twin‐to‐twin transfusion syndrome (TTTS), but imaging patterns and temporal evolution remain poorly defined. This study aimed to characterize the progression of severe brain injury after FLA. Methods We conducted a retrospective case series of TTTS
Yada Kunpalin +8 more
wiley +1 more source
Prediabetes, Malignant Ventricular Hypertrophy and Stroke: The SPRINT Trial
ABSTRACT Aims Prediabetes and left ventricular hypertrophy (LVH) are common risk factors in adults with hypertension. Whether their coexistence, particularly in the presence of subclinical myocardial injury or stress (malignant LVH), confers a heightened stroke risk is unknown.
Arnaud D. Kaze +7 more
wiley +1 more source

