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Brain function depends on close matching between metabolic demands for oxygen and nutrients and removal of cellular waste. This requires continuous regulation of cerebral blood flow (CBF) to match the high metabolic demands. The topic of this chapter is cerebral pressure regulation i.e., the intrinsic response of the cerebral vasculature to changes in ...
Parisa Nikrouz +2 more
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Parisa Nikrouz +2 more
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Phase dynamics in cerebral autoregulation
American Journal of Physiology-Heart and Circulatory Physiology, 2005Complex continuous wavelet transforms are used to study the dynamics of instantaneous phase difference Δφ between the fluctuations of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) in a middle cerebral artery. For healthy individuals, this phase difference changes slowly over time and has an almost uniform distribution for the ...
Miroslaw, Latka +5 more
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Clinical Significance of Cerebral Autoregulation
2002Disturbed cerebral autoregulation is believed to be associated with an unfavourable outcome following head injury. Previously, using ICP monitoring and transcranial Doppler ultrasonography, we investigated whether cerebral response to spontaneous variations in arterial pressure (ABP) or cerebral perfusion pressure (CPP) provide reliable information on ...
M, Czosnyka +3 more
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Influence of nitroprusside on cerebral pressure autoregulation
Neurosurgery, 1979The authors studied 10 cats to assess the question of abolition of cerebral autoregulation attendant on the use of nitroprusside for hypotensive anesthesia. After the establishment of stable base line parameters, a continuous infusion of sodium nitroprusside was begun in a dose sufficient to maintain a mean systemic arterial pressure of 65 mm Hg ...
M H, Weiss +5 more
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Cerebrovascular and brain metabolism reviews, 1990
Autoregulation of blood flow denotes the intrinsic ability of an organ or a vascular bed to maintain a constant perfusion in the face of blood pressure changes. Alternatively, autoregulation can be defined in terms of vascular resistance changes or simply arteriolar caliber changes as blood pressure or perfusion pressure varies.
Paulson, O B +2 more
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Autoregulation of blood flow denotes the intrinsic ability of an organ or a vascular bed to maintain a constant perfusion in the face of blood pressure changes. Alternatively, autoregulation can be defined in terms of vascular resistance changes or simply arteriolar caliber changes as blood pressure or perfusion pressure varies.
Paulson, O B +2 more
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Nonstationarity of dynamic cerebral autoregulation
Medical Engineering & Physics, 2013Dynamic cerebral autoregulation (dCA), the transient response of cerebral blood flow (CBF) to rapid changes in arterial blood pressure (BP), is usually quantified by parameters extracted from time- or frequency-domain analysis. Reproducibility studies of dCA parameters and consideration of the physiological determinants of the dynamic BP-CBF ...
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Oxygen-dependent mechanisms in cerebral autoregulation
Annals of Biomedical Engineering, 1985Autoregulatory adjustments in the caliber of cerebral arterioles were studied in anesthetized cats equipped with cranial windows for the direct observation of the pial microcirculation. Increased venous pressure caused slight, but consistent, arteriolar dilation, at normal and at reduced arterial blood pressure and irrespective of whether or not ...
H A, Kontos, E P, Wei
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The Frequency-Dependent Behavior of Cerebral Autoregulation
Neurosurgery, 1990Abstract Cerebral autoregulation is a complex physiological process composed of both fast and slow components that may respond differently to different rates and patterns of blood pressure variation. To assess the temporal nature of autoregulation, transcranial Doppler velocity recordings of the middle cerebral artery obtained over ...
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Cerebral Autoregulation and Vasomotor Reactivity
2006Various aspects of the cerebral blood-flow regulation can be assessed by transcranial Doppler (TCD). This chapter describes and discusses the approaches that have been reported in the literature. The steady-state characteristics of the cerebral autoregulation can be determined by changing the blood pressure level, and calculating the response of the ...
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