Results 161 to 170 of about 580,671 (347)

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Advanced Science, EarlyView.
Fumadó Navarro et al. present an optimized strategy to generate vascular‐like networks that infiltrate within cerebral organoids with promising signs of blood‐brain barrier characteristics, preserved stiffness, uniform morphology, enhanced media diffusion, and reduced necrotic core.
Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, Shane Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay Pandit, Mihai Lomora   +7 more
wiley   +1 more source

Measurement of Local Cerebral Blood Flow in the Unanesthetized Rat Using a Hydrogen Clearance Method

, 1968
Joseph L. Haining, Mark D. Turner, RALPH M. PANTALL   +2 more
openalex   +1 more source

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

Advanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu   +8 more
wiley   +1 more source

Relation between Cerebral Blood Flow and Time Required for Tonal Sensation in Conditioned Rhesus Monkeys [PDF]

, 1967
Warren Creel, Samuel Ralph Powers, Paul C. Boomsliter   +2 more
openalex   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

Advanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang, Fengzhi Qiao, Jian He, Jianxin Fu, Tongjie Liu, Huaxi Yi, Qinghai Sheng, Lanwei Zhang, Kai Lin   +8 more
wiley   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Clinical Utility of eZIS in Cerebral Blood Flow SPECT. [PDF]

Diagnostics (Basel)
Yamamoto S, Yoshida N, Sakurai N, Okada Y, Satoh M, Takeshita K, Nakai M, Abe K, Yoshimura M, Saito K.   +9 more
europepmc   +1 more source

CEREBRAL BLOOD FLOW DURING HALOTHANE ANAESTHESIA

, 1963
D. G. McDowall, A. M. Harper, I. Jacobson   +2 more
openalex   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source