Results 241 to 250 of about 602,288 (337)

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

Acute cerebral blood flow and its connectivity in patients with anti-LGI1 autoimmune encephalitis: an arterial spin labeling study. [PDF]

Brain Imaging Behav
Jiang P, Wang L, Sun D, Miao A, Wang X.
europepmc   +1 more source

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1‐mediated macrophage polarization via the PI3K/Akt pathway

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang, Tian Li, Weiran Jia, Dingjie Xu, Liangdan Sun, Yanlei Ge, Yiwei Shi, Hong Xu, Xudong Song, Fuyu Jin, Na Mao   +10 more
wiley   +1 more source

CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight. [PDF]

Neurophotonics
Parfentyeva V, Behera A, Avtzi S, Tran-Van-Minh A, Etard O, Freer S, Tambe T, Mehmed A, Isufaj A, Goodrich J, Ibrahim Y, Singh N, Darabi S, Villar Sanjurjo P, Malde S, Ali T, Kim Y, Sturniolo S, Ruesch A, Hill DW, Salehi Lashkajani A, Zhang Y, McCarthy P, Hu X, Antrobus A, Maine C, Thackrah M, Valley MT, Crutchley B, Borycki D, Dragojević T, Lindner C, Cooper RJ.   +32 more
europepmc   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy. [PDF]

Neurophotonics
Sabaghian S, Poon CS, Kim C, Moore CH, Dar I, Rambo TM, Miller AJ, Swarna S, Lubin N, Mofakkam S, Mikell C, Wang J, Foreman B, Sunar U.   +13 more
europepmc   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Assessment of dynamic cerebral blood flow changes during cognitive tasks in patients with post-COVID-19 syndrome. [PDF]

Brain Commun
Kutz DF, Garbsch R, Mooren FC, Schmitz B, Voelcker-Rehage C.   +4 more
europepmc   +1 more source