Results 291 to 300 of about 339,980 (337)

TREM2 Downregulation Disrupts Microglial Function and Synaptic Pruning Through RA/RARα Signaling: Mechanisms Underlying Autism‐Like Behaviors

Pediatric Discovery, EarlyView.
Downregulation of TREM2 induces autism‐like behaviors in healthy rats by impairing microglial function and triggering aberrant synaptic pruning. RA/RARα signaling pathway modulates alterations in TREM2 expression. Serum sTREM2 levels correspond to alterations in brain TREM2 expression.
Min Lu, Kexin Bai, Yali Bai, Yuan Miao, Tingjiao Zhao, Yi Yang, Jie Chen, Ting Yang, Tingyu Li, Hua Wei   +9 more
wiley   +1 more source

Dynamic relationships between bilirubin concentrations and the gut microbiota in the neonatal period: A pilot prospective cohort study

Pediatric Investigation, EarlyView.
In the prospective cohort of term neonates, daily bilirubin monitoring combined with serial fecal 16S rRNA sequencing showed that early gut microbiota trajectories are linked to bilirubin dynamics, with distinct bacterial genera associated with higher versus lower peak bilirubin.
Zhongyuan Li, Yan Zhang, Xi Luo, Yangyang Wang, Lihua Peng, Liping Zou   +5 more
wiley   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Advances in Factors and Risk Prediction of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt

Portal Hypertension &Cirrhosis, EarlyView.
Hepatic encephalopathy (HE) is a frequent complication that arises subsequent to transjugular intrahepatic portosystemic shunt (TIPS) procedures, with a considerable impact on patient prognosis. The occurrence of HE is influenced by multiple factors, and various risk prediction models have been developed in recent years to forecast its development post‐
Lixin Song, Xinyi Qiao, Yu Sun, Hui Yang
wiley   +1 more source

The Role of Meteorological Factors in Cerebral Anterior versus Posterior Circulation Aneurysm Rupture

Ksenia Yarovaya, Yuliia Solodovnikova, Anatoliy Son   +2 more
openalex   +1 more source

Non‐Targeted Analysis of Extracellular Vesicle‐Enriched Plasma Proteome Between Early and Late Rugby Playing Career

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Purpose Rugby players experience high‐impact collisions, potentially increasing their risk of neurodegenerative conditions. This study investigates whether the plasma proteome of extracellular vesicles (EV) provides biomarkers to indicate differential risk associated with a rugby career.
Abhishek Jagan, Yusuke Nishimura, Tim Donnovan, Jatin G. Burniston   +3 more
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Cerebral collateral circulation in experimental ischemic stroke: from molecular penumbra to collateral therapeutics

, 2015
Elisa Cuccione
openalex   +1 more source

Cerebral circulation

, 1889
openaire   +1 more source

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Rheology of the Cerebral Circulation

Neurosurgery, 1984
Current concepts of brain perfusion focus on the importance of rheological factors in the determination of cerebral blood flow. Blood viscosity, a primary determinant of blood flow, increases as the shear rate (velocity gradient) decreases, thereby impeding cerebral perfusion.
D B, Kee, J H, Wood
openaire   +2 more sources