Results 81 to 90 of about 339,980 (337)

The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension

Journal of Molecular and Cellular Cardiology Plus
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent failure remain a clinical challenge.
Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Vasco Sequeira, Md Junayed Nayeem, Mikiyasu Shirai, James T. Pearson, Takeshi Ogo   +7 more
doaj   +1 more source

The Functional State of the Cerebral Circulation Depending on the Localization of Transition Area in Chest Lead of ECG at Orthostasis

Наука. Инновации. Технологии, 2022
The article is devoted to the study of the functional state of the cerebral circulation at orthostasis in persons of young age with different localization of transition area in chest lead of ECG.
Polina Leonidovna Sevriukova, Galina Erdnevna Nastinova, Laura Andreevna Tovmasian, Polina Leonidovna Sevriukova   +3 more
doaj  

The changing landscape of chronic thromboembolic pulmonary hypertension management

European Respiratory Review, 2017
For patients with chronic thromboembolic pulmonary hypertension (CTEPH), the current standard of care involves surgical removal of fibro-thrombotic obstructions by pulmonary endarterectomy.
Michael Madani, Takeshi Ogo, Gérald Simonneau   +2 more
doaj   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Unilateral Antegrade Cerebral Perfusion versus Deep Hypothermic Circulatory Arrest during Acute Aortic Dissection Repair: A Single Center Experience

Acta Clinica Croatica, 2022
Introduction: The gold standard of circulation strategy and arterial cannulation during acute aortic dissection is still indisputable. Unilateral/bilateral antegrade cerebral perfusion (UACP/BACP) and deep hypothermic circulatory arrest (HCA) remains a
Mehmet Karaçalılar, Mugisha Kyaruzi
doaj  

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Ruptured Fisher grade 3 blister aneurysms have a higher incidence of delayed cerebral ischemia than ruptured Fisher grade 3 saccular aneurysms

Brain Circulation, 2020
BACKGROUND: Blister aneurysms are a rare subclass of aneurysms, which remain challenging to treat both with open cerebrovascular and endovascular techniques, and clinicians continue to see poor outcomes in some cases despite improvements in technology ...
Tejas Karnati, Tamar R Binyamin, Brian C Dahlin, Ben Waldau   +3 more
doaj   +1 more source

Cardiovascular function and ballistocardiogram: a relationship interpreted via mathematical modeling [PDF]

, 2019
Objective: to develop quantitative methods for the clinical interpretation of the ballistocardiogram (BCG). Methods: a closed-loop mathematical model of the cardiovascular system is proposed to theoretically simulate the mechanisms generating the BCG ...
Despins, Laurel, Enayati, Moein, Guidoboni, Giovanna, Huxley, Virginia H., Keller, James, Popescu, Mihail, Sacco, Riccardo, Sala, Lorenzo, Skubic, Marjorie, Szopos, Marcela   +9 more
core   +2 more sources

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Functional stability of cerebral circulatory system [PDF]

The functional stability of the cerebral circulation system seems to be based on the active mechanisms and on those stemming from specific of the biophysical structure of the system under study.
Moskalenko, Y. Y.
core   +1 more source