Results 71 to 80 of about 558,623 (254)

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Microbiome modulation and behavioural improvements in children with fragile X syndrome following probiotic intake: A pilot study

Scientific Reports
The gut microbiome (GM) is increasingly recognized as a key modulator of neurodevelopment via the microbiome-gut-brain axis. Fragile X syndrome (FXS), the most common inherited monogenic cause of intellectual disability, shares behavioural and molecular ...
Dragana Protic, Danijela Bascarevic, Sanja Dimitrijevic, Jovan Pesovic, Vladimir Nikolic, Sasa Nikolic, Velibor Novicevic, Jovana Markovic, Irena Arandjelovic, Dusanka Savic-Pavicevic, Margo Diricks, Meriem Belheouane, Matthias Merker   +12 more
doaj   +1 more source

Whey- vs Casein-Based Enteral Formula and Gastrointestinal Function in Children With Cerebral Palsy. [PDF]

, 2012
Objectives: Children with severe cerebral palsy (CP) commonly have gastrointestinal (GI) dysfunction. Whey-based enteral formulas have been postulated to reduce gastroesophageal reflux (GOR) and accelerate gastric emptying (GE).
Schwarzer, A., Savage, K., Kritas, Stamatiki, Omari, T., Davidson, Geoffrey, Kritas, S., Davidson, G., Savage, Karina, Schwarzer, Andrea, Omari, Taher   +9 more
core   +1 more source

Innovation of plant‐derived extracellular vesicles and interdisciplinary research: From discovery to biomedical applications

BMEMat, EarlyView.
Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li, Yi Wei, Ben Hu, Yafang Song, Xiaojia Chen, Nik Ahmad Nizam Nik Malek, Tongkai Chen   +6 more
wiley   +1 more source

MRI patterns and clinical outcomes in cerebral palsy: insights from a large MRICS-based cohort

Journal of Neurodevelopmental Disorders
Background To classify MRI patterns in children with cerebral palsy (CP) using the MRI Classification System (MRICS) and examine their associations with perinatal risk factors and clinical outcomes.
Junying Yuan, Kejie Cao, Dong Li, Jiefeng Hu, Xuejie Wang, Wending Xin, Lingling Zhang, Yiran Xu, Changlian Zhu   +8 more
doaj   +1 more source

Early neurological and developmental trajectories of infants at high risk of cerebral palsy in Bangladesh: a prospective longitudinal cohort study

BMJ Paediatrics Open
Background Longitudinal data for high-risk infants in the first 2 years of life are limited, particularly in low- and middle-income countries. We aimed to describe survival, diagnostic, neurological and developmental outcomes of infants at risk of ...
Catherine Morgan, Nadia Badawi, Saifuddin Ahmed, Iona Novak, Nazrul Islam, Mohammad Muhit, Gulam Khandaker, Tasneem Karim, Annabel Webb, Shafiul Islam, Anna te Velde, Iskander Hossain   +11 more
doaj   +1 more source

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

Comparison between semitendinosus transfer to distal femur and medial hamstrings surgical lengthening for treatment of flexed knee gait in cerebral palsy

Journal of Orthopaedic Surgery, 2020
Purpose: Hamstrings surgical lengthening (HSL) has been frequently used for the treatment of flexed knee gait in cerebral palsy; however, recurrence of knee flexion deformity (KFD) and increase of anterior pelvic tilt (APT) were reported in a long-term ...
Mauro César de Morais Filho, Marcelo Hideki Fujino, Francesco Camara Blumetti, Carlos Alberto dos Santos, Cátia Miyuki Kawamura, Bruna Caroline Alexandrino Ramos, José Augusto Fernandes Lopes   +6 more
doaj   +1 more source

Fetal and maternal candidate single nucleotide polymorphism associations with Cerebral Palsy: a case-control study

, 2012
ObjectivePrevious studies have suggested associations between certain genetic variants and susceptibility to cerebral palsy (CP). This study was designed to assess established and novel maternal and child genetic and epidemiologic risk factors for CP ...
McMichael, Gai L., Painter, Jodie N., Montgomery, G., O'Callaghan, M., Painter, J., Goldwater, Paul N., Dekker, G., Dekker, Gus A., O'Callaghan, Michael E., Gibson, C., Montgomery, Grant W., Gibson, Catherine S., Broadbent, J., MacLennan, A., Goldwater, P., MacLennan, Alastair H., Haan, Eric A., Haan, E., Broadbent, Jessica L., McMichael, G.   +19 more
core   +1 more source

USING THE METHOD KINESIOTAPING IN REHABILITATION OF CHILDREN WITH HEMIPARETIC FORM OF CEREBRAL PALSY [PDF]

, 2016
The study examines the impact of a new kind of impact in the rehabilitation of hemiparetic form of cerebral palsy – a method kinesiotaping «Concept 4 tapes».
Kvashuk, Pavel, Kiselev, Anatolevich Dmitry, Tuchkov, Vladimir Evgenevich, Kiselev, Dmitry, Vladimir Evgenevich Tuchkov, Pavel Valentinovich Kvashuk, Tuchkov, Vladimir, Anatolevich Dmitry Kiselev, Kvashuk, Pavel Valentinovich   +8 more
core   +1 more source