Results 131 to 140 of about 259,881 (379)

Review of hypoxaemia in the anaesthetized horse: predisposing factors, consequences and management [PDF]

, 2017
Objectives: To discuss how hypoxaemia might be harmful and why the horse is particularly predisposed to developing it. To review the strategies that are used to manage hypoxaemia in anaesthetised horses, to describe how successful these strategies are
Auckburally, Adam, Nyman, Görel
core   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

Defining metabolic abnormalities in acute human traumatic brain injury with cerebral microdialysis and multimodality monitoring.

PLoS ONE
ObjectiveWe aimed to compare the prevalence and multimodal associations of mitochondrial dysfunction as defined by published cerebral-microdialysis-based criteria versus our novel multimodality-monitoring-based criteria in acute traumatic brain injury ...
Michael S Baker, Sara Venturini, Caroline Lindblad, Joshua M Heihre, Ivan Timofeev, Mathew R Guilfoyle, Peter J Hutchinson, Keri L H Carpenter, Adel Helmy   +8 more
doaj   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

A Metalloporphyrin Nanosystem Enables Non‐Invasive Visualization and Specific Treatment for Thrombosis and Ischemic Stroke

Advanced Science, EarlyView.
Thrombotic ischemic stroke is a severe neurological disease of the brain that presents major challenges for effective diagnosis and treatment. Precisely engineered Ir and Mn cores within a single porphyrin framework of 4IrMn nanoparticles enable endogenous ONOO−‐ or laser‐activated switching among NIR‐CL imaging, photothermal / photodynamic therapy ...
Ziwei Wang, Liping Zhang, Zihan Wu, Nan Xiao, Wenxin Zheng, Yachao Wang, Gelin Xu, Dongxia Zhu, Martin R. Bryce, Lijie Ren, Ben Zhong Tang   +10 more
wiley   +1 more source

Study on in Vivo Pial Vessels Alterations and Activity of Isolated Vascular Smooth Muscles in Abdominal Hypertension Rats

Folia Medica, 2019
Background: Intra-abdominal hypertension is known as a factor affecting cerebral haemodynamics. Sustainably elevated abdominal pressure may disturb the balance of intracranial/blood pressure ratio, eventually developing perfusion pressure to drop.
Turiyski Valentin I., Vassilev Petar G., Ardasheva Raina G., Dobrev Hristo P., Kristev Athanas D.   +4 more
doaj   +1 more source

Impaired cerebral autoregulation, cerebral perfusion pressure, and intracranial pressure in eclampsia [PDF]

American Journal of Obstetrics and Gynecology, 2022
Lina Bergman, Catherine Cluver, Niclas Carlberg, Michael Belfort, Mary C. Tolcher, Ronney B. Panerai, Teelkien Van Veen   +6 more
openaire   +2 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Cerebral hypoperfusion resulting from improper cannulation positioning during aortic dissection surgery: a case report

Journal of Cardiothoracic Surgery
Background Selective antegrade cerebral perfusion (sACP) is a crucial cerebral protection technique employed during aortic dissection surgeries involving cardiopulmonary bypass.
Qingping Xia, Fei Lin, Yong Cao, Li Deng
doaj   +1 more source

Cerebrovascular Hemodynamics during Concentric and Eccentric Phases of Heavy Resistance Exercise [PDF]

, 2013
Rapid and drastic fluctuations in arterial blood pressures, such as those occurring during heavy resistance exercise pose a unique challenge to the maintenance of cerebral perfusion. During high-intensity leg cycling, regulation of cerebral perfusion is
Cooke, William H, Moralez, Gilbert, Raven, Peter B, Rickards, Caroline A, Romero, Steven A.   +4 more
core   +1 more source