Results 141 to 150 of about 259,881 (379)

Cerebral Perfusion Pressure Targets in Traumatic Brain Injury: The “Fuzzy” Spots Above Optimal Cerebral Perfusion Pressure [PDF]

, 2018
Frederick A. Zeiler
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

Advanced Science, EarlyView.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt, Elizaveta Melnikova, Eugenio Gutiérrez, Vladimir Matchkov, Leif Østergaard, Dmitry D Postnov   +5 more
wiley   +1 more source

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

Advanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang, Min Shi, Qun Hou, Jiehong Yang, Chen Ding, Wei Fu, Buchang Zhao, Haitong Wan   +16 more
wiley   +1 more source

Cerebral perfusion pressure and behavior monitoring in freely moving rats. [PDF]

Physiol Res, 2023
Kozler P, Marešová D, Hrachovina M, Pokorný J.   +3 more
europepmc   +1 more source

The Effects of Isoflurane and Desflurane on Intracranial Pressure, Cerebral Perfusion Pressure, and Cerebral Arteriovenous Oxygen Content Difference in Normocapnic Patients with Supratentorial Brain Tumors [PDF]

, 2003
Marcial Fraga, P. Rama‐Maceiras, S Rodiño, Humberto Aymerich, P Pose, Javier Belda   +5 more
openalex   +1 more source

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility

Autism Research, EarlyView.
ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability.
Dorit Möhrle, Demi Ma, Wenyue Xue, Jun Yan, Ning Cheng   +4 more
wiley   +1 more source

Dissociation of Cerebral Blood Flow and Femoral Artery Blood Pressure Pulsatility After Cardiac Arrest and Resuscitation in a Rodent Model: Implications for Neurological Recovery. [PDF]

, 2020
Background Impaired neurological function affects 85% to 90% of cardiac arrest (CA) survivors. Pulsatile blood flow may play an important role in neurological recovery after CA.
Akbari, Yama, Bazrafkan, Afsheen, Choi, Bernard, Crouzet, Christian, Lee, Donald, Tromberg, Bruce J, Wilson, Robert H   +6 more
core   +1 more source

Transcranial color-coded duplex sonography allows to assess cerebral perfusion pressure noninvasively following severe traumatic brain injury [PDF]

, 2010
Giovanna Brandi, Markus Béchir, Susanne Sailer, C. Haberthür, Reto Stocker, John Stover   +5 more
openalex   +1 more source