Results 21 to 30 of about 137,378 (339)

Early cerebral perfusion pressure augmentation with phenylephrine after traumatic brain injury may be neuroprotective in a pediatric swine model* [PDF]

, 2012
Objective: Cerebral perfusion pressureage, and current guidelines recommend maintaining cerebral perfusion pressure between 40 mm Hg–60 mm Hg. Although adult traumatic brain injury studies have observed an increased risk of complications associated with ...
Adelson, Adelson, Armstead, Armstead, Armstead, Bedforth, Broderick, Chambers, Chambers, Cherian, Contant, Cunningham, De Cosmo, Di Gennaro, Dudkiewicz, Duhaime, Eucker, Friess, Friess, Hannon, Hillered, Jackson, Llinas, Malhotra, Nordstrom, Raghupathi, Raghupathi, Rajan, Robertson, Slawik, Sookplung, Stiefel   +31 more
core   +2 more sources

A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways). [PDF]

, 2014
Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological ...
Applegate, Patricia M, Applegate, Richard L, Gatling, Jason W, Huang, Lei, Mangus, Dustin B, Zhang, John   +5 more
core   +5 more sources

Análise da capacidade reactiva da circulação intracerebral pelo efeito do CO2. Um método de fácil execução.

Acta Médica Portuguesa, 1998
Maintenance of cerebral perfusion pressure is a prerequisite for the prevention of cerebral ischaemia. Physiological fluctuations in systemic perfusion pressure are compensated by cerebrovascular autoregulation.
A Baptista, J Ribeiro
doaj   +1 more source

Intrathoracic pressure regulation therapy applied to ventilated patients for treatment of compromised cerebral perfusion from brain injury

Journal of Medical Case Reports, 2018
Background Reducing intrathoracic pressure in the setting of compromised cerebral perfusion due to acute brain injury has been associated with reduced intracranial pressure and enhanced cerebral perfusion pressure and blood flow in animals.
Anja K. Metzger, Nicolas Segal, Dai Wai Olson, Stephen A. Figueroa, Farid G. Sadaka, Catherine A. Krause, James R. Homuth, Nathaniel T. Burkhart, Robert T. Neumann, Keith G. Lurie, Victor A. Convertino   +10 more
doaj   +1 more source

Cerebral Perfusion Pressure Directed-Therapy Modulates Cardiac Dysfunction After Traumatic Brain Injury to Influence Cerebral Autoregulation in Pigs. [PDF]

Neurocrit Care, 2019
Armstead WM, Vavilala MS.
europepmc   +3 more sources

Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease The PRESERVE Randomized Clinical Trial [PDF]

, 2018
Importance: Blood pressure lowering is considered neuroprotective in patients with cerebral small vessel disease, however more “intensive” regimens may increase cerebral hypoperfusion. We examined the effect of intensive vs.
Barrick, TR, Blamire, AM, Cambridge, VC, Croall, ID, Ford, GA, Khan, U, Markus, HS, Morris, RG, Moynihan, B, O'Brien, JT, PRESERVE Study Team, Tozer, DJ   +11 more
core   +1 more source

Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]

, 2004
<p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C., Harazny, J., Hilgers, K.F., Michelson, G., Oehmer, S., Schmieder, R.E.   +5 more
core   +1 more source

Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography [PDF]

, 2011
Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation.
Barrie Condon, Celestine Santosh, Christopher McCabe, Craig A Robertson, I Mhairi Macrae, Keith W Muir, Kucinski T, Lindsay Gallagher, Maria del Rosario Lopez-Gonzalez, William M Holmes   +9 more
core   +1 more source

PTPRG is an ischemia risk locus essential for HCO3–-dependent regulation of endothelial function and tissue perfusion

eLife, 2020
Acid-base conditions modify artery tone and tissue perfusion but the involved vascular-sensing mechanisms and disease consequences remain unclear. We experimentally investigated transgenic mice and performed genetic studies in a UK-based human cohort. We
Kristoffer B Hansen, Christian Staehr, Palle D Rohde, Casper Homilius, Sukhan Kim, Mette Nyegaard, Vladimir V Matchkov, Ebbe Boedtkjer   +7 more
doaj   +1 more source

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]

, 2019
No abstract ...
Berry, C, Ford, TJ, Hainsworth, AH, Kaski, JC, Pereira, AC, Sidik, N, Touyz, RM   +6 more
core   +2 more sources