Results 191 to 200 of about 435,514 (353)

3D Vessel Graph Generation Using Denoising Diffusion [PDF]

arXiv
Blood vessel networks, represented as 3D graphs, help predict disease biomarkers, simulate blood flow, and aid in synthetic image generation, relevant in both clinical and pre-clinical settings. However, generating realistic vessel graphs that correspond to an anatomy of interest is challenging.
arxiv  

Expanding the Tyrosine Kinase Domain of CSF1R? A Case Report From an Adult‐Onset Leukoencephalopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), also termed hereditary diffuse leukoencephalopathy with spheroids‐1 (HDLS1), results from mutations in the CSF1R gene and leads to progressive leukoencephalopathy.
Piervito Lopriore, Gianmichele Migaleddu, Pei‐Chien Tsai, Antonella Fogli, Maria Adelaide Caligo, Gabriele Siciliano, Mirco Cosottini, Yi‐Chung Lee, Yi‐Chu Liao, Michelangelo Mancuso, Roberto Ceravolo, Daniela Frosini   +11 more
wiley   +1 more source

Impact of blood pressure variability and cerebral small vessel disease: A systematic review and meta-analysis

Heliyon
Importance: Abnormal blood pressure pattern is an independent risk factor for vascular events. Blood pressure variability can predict cardiovascular and cerebrovascular disease outcomes and is closely associated with the risk of cognitive impairment ...
Bingqing Zhao, Weihua Jia, Ye Yuan, Ying Chen, Yali Gao, Baoling Yang, Wei Zhao, Jingyi Wu   +7 more
doaj  

Retinal structure and vessel density changes in cerebral small vessel disease

Frontiers in Neuroscience
BackgroundCerebral small vessel disease (CSVD) attaches people’s attention in recent years. In this study, we aim to explore retinal structure and vessel density changes in CSVD patients.MethodsWe collected information on retinal metrics assessed by ...
Dandan Wang, Lina Wang, Jinjin Wang, Yang Du, Kaiyue Wang, Meizi Wang, Liu Yang, Xingquan Zhao, Xingquan Zhao   +8 more
doaj   +1 more source

Connectomic-genetic signatures in the cerebral small vessel disease

Neurobiology of Disease, 2022
Small vessel disease (SVD) is a disorder that causes vascular lesions in the entire parenchyma of the human brain. At present, it is not well understood how primary and secondary damage interact to give rise to the complex scenario of white matter (WM ...
Raquel Gutiérrez-Zúñiga, Ibai Diez, Elisenda Bueichekú, Chan-Mi Kim, William Orwig, Victor Montal, Blanca Fuentes, Exuperio Díez-Tejedor, Maria Gutiérrez Fernández, Jorge Sepulcre   +9 more
doaj  

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

CircUCK2 regulates HECTD1‐mediated endothelial‐mesenchymal transition inhibition by interacting with FUS and protects the blood–brain barrier in ischemic stroke

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 1, Page 40-51, January 2023., 2023
Abstract Ischemic stroke (IS) has become a cerebrovascular disease of widespread concern. Overexpression of circUCK2 alleviates neuronal damage in IS. However, the specific regulatory mechanisms of circUCK2 are not fully understood. In this study, we found that circUCK2 and HECT domain E3 ubiquitin ligase 1 (HECTD1) were downregulated in IS models in ...
Jun‐Hong Zhuang, Huan‐Xiong Chen, Ning Gao, Rong‐Dao Sun, Cheng‐Ye Xiao, De‐Hua Zeng, Zheng‐Tao Yu, Jun Peng, Ying Xia   +8 more
wiley   +1 more source

Association of pulsatility index with total burden of cerebral small vessel disease and cognitive impairment

Brain and Behavior
Objective This study investigated the correlation between the pulsatility index (PI) of the middle cerebral artery with the total burden of cerebral small vessel disease and cognitive impairment.
Huijuan Wu, Liaoyang Xu, Xingyongpei Zheng, Caihong Gu, Xinyu Zhou, Yong Sun, Xiaomin Li   +6 more
doaj   +1 more source

Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Poor cardiovascular health (CVH) is linked to Alzheimer's disease and dementia; however, its association with neurocognitive trajectories earlier in life remains underexplored. METHODS We included 3224 participants with information on CVH at early midlife (mean age 45.0 ± standard deviation 3.4) an cognitive assessments, and ...
Christina Silvia Dintica, Xiaqing Jiang, Lenore J. Launer, R. Nick Bryan, Kristine Yaffe   +4 more
wiley   +1 more source

Krüppel‐like factor 4 transcription factor in blood–brain barrier endothelial cells: A potential role in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei, Chunhua Liu, Jianyu Chen, Yuxiao Yao, Dajiang Qin   +4 more
wiley   +1 more source