Results 251 to 260 of about 435,514 (353)

Strengthening the link between periodic leg movements during sleep and cerebral small vessel disease. [PDF]

Sleep
Ferri R, Lanza G, Mogavero MP.
europepmc   +1 more source

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, EarlyView.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source

Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study

Movement Disorders, EarlyView.
Abstract Background Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring. Objective We set out to investigate the relationship between optic disc pallor measured in fundoscopy images
Samuel Gibbon, David P. Breen, Thomas J. MacGillivray, UK Biobank Eye & Vision Consortium   +3 more
wiley   +1 more source

Deep learning assisted retinal microvasculature assessment and cerebral small vessel disease in Fabry disease. [PDF]

Orphanet J Rare Dis
Li Y, Zhou X, Li J, Zhao Y, Yuan Y, Yang B, Xu J, Wei Q, Yan X, Zhang W, Wu Y.   +10 more
europepmc   +1 more source

Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods Forty‐nine subjects carrying mutant Huntingtin (mHTT), comprising 35 manifest (mHD) and 14 pre‐manifest (PreHD), and 35 healthy controls (HC) were recruited in this study.
Jin‐Hui Yin, Ling‐Xiao Cao, Ya‐Ou Liu, Yue Huang   +3 more
wiley   +1 more source

Hydrocephalus and Cerebral Small Vessel Disease in an Adult With Meningococcal Meningitis and Dilated Cardiomyopathy: A Fatal Outcome. [PDF]

Clin Case Rep
Mohamed Y, Mohamed A, Elemam A, Babiker A.   +3 more
europepmc   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Using individualized structural covariance networks to analyze the heterogeneity of cerebral small vessel disease with depressive states. [PDF]

Front Neurol
Zhang S, Chen Y, Zhou H, Zhao Z.
europepmc   +1 more source

Segmentation‐assisted vessel centerline extraction from cerebral CT Angiography

Medical Physics, EarlyView.
Abstract Background The accurate automated extraction of brain vessel centerlines from Computed tomographic angiography (CTA) images plays an important role in diagnosing and treating cerebrovascular diseases such as stroke. Despite its significance, this task is complicated by the complex cerebrovascular structure and heterogeneous imaging quality ...
Sijie Liu, Ruisheng Su, Jianghang Su, Wim H. van Zwam, Pieter Jan van Doormaal, Aad van der Lugt, Wiro J. Niessen, Theo van Walsum   +7 more
wiley   +1 more source