Results 31 to 40 of about 37,238 (263)

Basic and Translational Research on Proteinase-Activated Receptors: The Role of Thrombin Receptor in Cerebral Vasospasm in Subarachnoid Hemorrhage

Journal of Pharmacological Sciences, 2008
Cerebral vasospasm is one of the major complications of subarachnoid hemorrhage (SAH). The prevention and treatment of cerebral vasospasm thus plays a critical role in the management of SAH patients.
Yasutoshi Kai, Yoshihisa Maeda, Tomio Sasaki, Hideo Kanaide, Katsuya Hirano   +4 more
doaj   +1 more source

Symptomatic Cerebral Vasospasm after Surgical Ligation of Unruptured Aneurysms [PDF]

, 2009
Background Cerebral artery vasospasm accounts for the majority of delayed neurological deficits in ruptured aneurysm patients. We report two cases and review the literature of patients who developed symptomatic vasospasm after treatment for unruptured ...
Harrop, James, MD, Rosenwasser MD, Robert H.   +1 more
core   +2 more sources

Ventral Intramedullary Cervical Spinal Cord AVM [PDF]

, 2009
Background Cerebral artery vasospasm accounts for the majority of delayed neurological deficits in ruptured aneurysm patients. We report two cases and review the literature of patients who developed symptomatic vasospasm after treatment for unruptured ...
Jabbour, Pascal, MD, Rosenwasser MD, Robert H., Yadla, Sanjay, MD   +2 more
core   +2 more sources

Pathogenic mechanisms and therapeutic implications of extracellular matrix remodelling in cerebral vasospasm

Fluids and Barriers of the CNS, 2023
Cerebral vasospasm significantly contributes to poor prognosis and mortality in patients with aneurysmal subarachnoid hemorrhage. Current research indicates that the pathological and physiological mechanisms of cerebral vasospasm may be attributed to the
Ziliang Hu, Xinpeng Deng, Shengjun Zhou, Chenhui Zhou, Menglu Shen, Xiang Gao, Yi Huang   +6 more
doaj   +1 more source

Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]

, 2016
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois, Diringer, Michael N, Etminan, Nima, Faleck, Herbert J, Hanggi, Daniel, Hoh, Brian L, Macdonald, R. Loch, Mayer, Stephen A, Mocco, J, Newton Investigators,, Steiger, Hans Jakob   +10 more
core   +3 more sources

Intra‐arterial infusion of fasudil hydrochloride to treat post‐traumatic cerebral vasospasm

Acute Medicine & Surgery, 2019
Background The effect of intra‐arterial infusion of fasudil hydrochloride in patients with post‐traumatic cerebral vasospasm remains unclear. Here we report a case of intra‐arterial infusion of fasudil hydrochloride for post‐traumatic cerebral vasospasm.
Tomoaki Murakami, Ryuichiro Kajikawa, Hajime Nakamura, Takeshi Nishida, Kazuhiro Yoshimura, Tomoyuki Yoshihara, Koichiro Tsuruzono, Akatsuki Wakayama, Haruhiko Kishima   +8 more
doaj   +1 more source

Can S100B predict cerebral vasospasms in patients suffering from subarachnoid hemorrhage?

Frontiers in Neurology, 2013
Background: Protein S100B has proven to be a useful biomarker for cerebral damages. Increased levels of serum and CSF S100B have been shown in patients suffering subarachnoid hemorrhage, severe head injury and stroke.
Moshgan eAmiri, Moshgan eAmiri, Ramona eAstrand, Bertil eRomner   +3 more
doaj   +1 more source

Minimal long-term neurobehavioral impairments after endovascular perforation subarachnoid hemorrhage in mice [PDF]

, 2017
Cognitive deficits are among the most severe and pervasive consequences of aneurysmal subarachnoid hemorrhage (SAH). A critical step in developing therapies targeting such outcomes is the characterization of experimentally-tractable pre-clinical models ...
Brody, David L, Fanizzi, Claudia, Gangolli, Mihika, Kummer, Terrance T, Sauerbeck, Andrew D, Zipfel, Gregory J   +5 more
core   +2 more sources

Platelet factor 4 and stromal cell-derived factor are novel prognostic biomarkers for cerebral vasospasm and mortality after subarachnoid hemorrhage. [PDF]

Sci Rep
Khan D, Fischer I, Sahan S, Hewera M, Faust K, Muhammad S.   +5 more
europepmc   +3 more sources

ERYTHROPOIETIN FOR THE TREATMENT OF SUBARACHNOID HEMORRAGE: A FEASIBLE INGREDIENT FOR A SUCCESS MEDICAL RECIPE [PDF]

, 2015
Subaracnhoid hemorrage (SAH) following aneurysm bleeding accounts for 6% to 8% of all cerebrovascular accidents. Althoug an aneurysm can be effectively managed by surgery or endovascular therapy, delayed cerebral ischemia is diagnosed in a high ...
A Gorio, A Jackowski, A Nagai, AL Siren, AM Murphy, AV Santhanam, AV Santhanam, BB Beleslin-Cokic, C Alafaci, C Lacombe, CC Tan, Concetta Alafaci, D Banerjee, D Burger, E Gao, E Morishita, F Fiordaliso, FA Sehba, FA Sehba, FH Bahlmann, Francesco Cappello, G Chen, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, G Grasso, Giovanni Grasso, Giovanni Tomasello, H Bao, H Cai, H Kertmen, H Ohashi, HH Marti, I Cervellini, JB Bederson, JB Springborg, JB Springborg, JM Schmidt, JW Fisher, K Chin, K Franke, K Jacobs, K Koshimura, K Rosenlof, KH Su, L Cherian, L Cherian, L Costa da, L Jia, L Sautina, L Wang, LJ Ignarro, LV d’Uscio, LV d’Uscio, M Bernaudin, M Brines, M Brines, M Brines, M Brines, M Buemi, M Digicaylioglu, M Digicaylioglu, M Duval, M Kawakami, M Leist, M Migliori, M Sabri, M Sakanaka, Marcello Noto, ML Brines, MO Arcasoy, MY Tseng, N Dorsch, N Urao, OM Martinez-Estrada, P Kim, PW McCormick, R Merla, R Wang, RG Carlini, RM Pluta, S Dang, S Genc, S Masuda, SE Juul, SS Najjar, ST Lee, TJ Delgado, W Jelkmann, W Jelkmann, W Li, WC Sessa, Y Sadamoto   +101 more
core   +1 more source