Results 281 to 290 of about 97,560 (332)

Cerebral veins (diagram)

, 2015
openaire   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Paroxysmal nocturnal hemoglobinuria revealed by atypical thromboses: A case of cerebral, hepatic, and portal vein involvement leading to cirrhosis. [PDF]

Radiol Case Rep
Malghi M, Zouaoui M, Bamaarouf I, Messaoudi S, Hnach Y, Azouaoui M, Aqodad N.   +6 more
europepmc   +1 more source

Population Pharmacokinetics of Asundexian in People at Risk for Thromboembolic/Cardiovascular Events

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Asundexian is a potent, selective, and reversible inhibitor of activated clotting Factor XI currently under development for secondary prevention of recurrent ischemic stroke in the ongoing Phase III OCEANIC‐STROKE study (NCT05686070). Here, we report the development of a population pharmacokinetic (popPK) model for asundexian.
Ashraf Yassen, Friederike Kanefendt, Jochen Zisowsky, Astrid Broeker, Hardi Mundl, Peter Vis, Dirk Garmann, Jan Berkhout   +7 more
wiley   +1 more source

Acute Subdural Hematoma Without Subarachnoid Hemorrhage Due to Traumatic Aneurysm of the Posterior Cerebral Artery. [PDF]

Cureus
Kuboyama M, Kimura T, Kugisaki A, Nambu S, Ichi S.   +4 more
europepmc   +1 more source

Biotechnical Multiscale Engineering of Scaffolds for Stem Cell and Organoid Research

Small, EarlyView.
Biotechnical multiscale engineering consideration of geometric and structural parameters, which is called biotechnical multiscale engineering, has an influence on stem cell development and organogenesis comparable to that of molecular genetics and biochemical parameters.
Merle‐Johanna Küstner, Christian Marx, Peter beim Graben, Serafim Rodrigues, Jörg Hampl, Frank Weise, Michael Gebinoga, Leon Kaysan, Maren Klett, Dana Brauer, Gregor Schlingloff, Doris Heinrich, Insa Sigrid Schroeder, Andreas Schober   +13 more
wiley   +1 more source

Longitudinal Neuroimaging of a Pediatric Patient With Sturge-Weber Syndrome: From Birth to Adolescence. [PDF]

Cureus
Rai B, Chaudhari B, Abubaker E, Jaradat S, Nandish S.   +4 more
europepmc   +1 more source

Activatable smart contrast agents for photoacoustic imaging

Smart Molecules, EarlyView.
This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim   +5 more
wiley   +1 more source

Hydrogel Microspheres for Biomedical Applications

Small Science, EarlyView.
Hydrogel microspheres (HMs) play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications.
Yingkang Huang, Xi Zhu, Jinhong Zhou, Henan Li, Wei Zhang, Danyang Shen, Ziyan Huang, Tianbo Zhang, Lin Zhuang, Lei Qin, Xiaofeng Xue, Yunjie Lu   +11 more
wiley   +1 more source

Sagittal Sinus Thrombosis and Ischemic Cerebrovascular Accident in a Patient With Ulcerative Colitis: A Case Report. [PDF]

Clin Case Rep
Kc N, Sharma S, Poudel S, Parajuli B, Kc R.   +4 more
europepmc   +1 more source