Results 161 to 170 of about 42,854 (222)

Research Progress of Annexin A1 and Its Derived Peptides in the Diagnosis and Treatment of Circulatory Diseases

open access: yesImmunity, Inflammation and Disease, Volume 13, Issue 11, November 2025.
ABSTRACT Background Annexin A1 (ANXA1), a calcium‐dependent phospholipid‐binding protein, plays a critical role in regulating inflammation, apoptosis, immune responses, and vascular remodeling. It is increasingly recognized for its potential as a therapeutic target and diagnostic biomarker in various circulatory diseases, including sepsis, hypertension,
Qiuyu Dai   +4 more
wiley   +1 more source

Pediatric liver transplantation. Part II. Diagnostic imaging in postoperative management [PDF]

open access: yes, 1985
Bron, KM   +6 more
core   +1 more source

The Evolving Trend of Liver Transplantation in Metabolic Diseases: From Origins to Current Perspectives

open access: yesJournal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Liver transplantation (LTx) has become, over the years, an increasingly used therapeutic option in patients with inherited metabolic diseases (IMD). Initially performed for Tyrosinemia Type I and ornithine transcarbamylase deficiency, it now accounts as the second indication for pediatric transplants worldwide. The use of LTx has been extended
Andrea Pietrobattista   +3 more
wiley   +1 more source

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): The Multifaceted Biology, Diseases, and Pharmaceutical Interventions

open access: yesMedComm, Volume 6, Issue 11, November 2025.
Summary of PCSK9 inhibitor mechanisms. PCSK9 inhibitors (PCSK9‐i) primarily lower LDL‐cholesterol (LDL‐C) by blocking PCSK9‐mediated degradation of hepatic LDL receptors (LDLR), enhancing LDL clearance. Beyond LDLR‐dependent effects, PCSK9‐i exert multiple benefits via LDLR‐independent pathways.
Jia Kuang   +3 more
wiley   +1 more source

Cerebral Venous Thrombosis with Migraine-Like Headache and the Trigeminovascular System [PDF]

open access: gold, 2016
Fábio A. Nascimento   +3 more
openalex   +1 more source

Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions

open access: yesMedComm, Volume 6, Issue 11, November 2025.
Allmang et al. demonstrated that ADAMTS13 is overexpressed in PDAC, associated with prolonged survival and reduced vascular density. Knockout of ADAMTS13 in PDAC cells led to a decrease in migration and invasion. In a xenograft model, loss of ADAMTS13 altered angiogenesis, vascular maturation, and reduced the expression of key angiogenic factors ...
Stephanie Allmang   +11 more
wiley   +1 more source

Perinatal Outcomes After the Use of Kampo Medicines Containing Ephedra During Pregnancy

open access: yesPharmacoepidemiology and Drug Safety, Volume 34, Issue 11, November 2025.
ABSTRACT Purpose Japanese traditional (Kampo) medicines containing ephedra are used to relieve symptoms of the common cold during pregnancy. The risks associated with perinatal outcomes, however, remain unclear. Thus, we evaluated the risk of adverse perinatal outcomes associated with the use of Kampo medicines containing ephedra during pregnancy using
Aoi Noda   +15 more
wiley   +1 more source

Treatment‐Specific Risk Scales for Identifying High‐Risk Patients With Poor Prognosis in Acute Ischemic Stroke: A Cohort Study From the National Neurological Medical Center of China

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
The PAIST prognostic tool, developed through thrombolysis‐based stratification and externally validated, effectively identifies AIS patients at high risk of acute‐phase adverse outcomes by integrating multidimensional variables, demonstrating superior predictive performance to support clinical management.
Yi Xu   +7 more
wiley   +1 more source

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